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Praise for Total Holographic Characterization:

"THC shows a significant superiority to FI and RMM in detecting heterogenous protein aggregates which often appear as transparent and porous particles."

FROM: The Journal of Pharmaceutical Sciences, The Strengths of Total Holographic Video Microscopy in Detecting Sub-Visible Protein Particles in Biopharmaceuticals: A Comparison to Flow Imaging and Resonant Mass Measurement

Harri Rahn*, Merve Oeztuerk, Nikolai Hentze, Friederike Junge, Markus Hollmann

AbbVie Deutschland GmbH & Co. KG, Knollstraße, Ludwigshafen 67061, Germany

"In this study, three techniques, including Raman microscope, BMI and THC, were screened to monitor the formation of FFA particles in placebo solution. The results indicated THC is the most suitable one, featuring high sensitivity, minimal interruption to samples and low interference from formulation matrices."

FROM: European Journal of Pharmaceutics and Biopharmaceutics, Screening Techniques for Monitoring the Sub-visible Particle Formation of Free Fatty Acids in Biopharmaceuticals

Wei Chen, Denis Klemm, Kathrin Gregoritza, Ravuri Satya Krishna Kishore, Jan Olaf Stracke, Christine Wurth, Cosimo Pinto, Nuria Sancho Oltra

F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland

Spheryx, with its revolutionary technique Total Holographic Characterization®, delivers solutions that provide a new window into suspensions at the sub-visible level.

Suspensions are a part of our daily lives from electronics, pharmaceuticals and industrial fluids to water quality, cosmetics, chemicals and petroleum products. All of these products must be analyzed throughout the development, manufacturing and quality assurance processes to ensure product quality and consistency.

Spheryx provides capabilities, never before possible, to develop and monitor products and provide improved information and control. The results will be better, more effective products, less waste, and increased efficiency, producing cost savings and improved market share.

Semiconductor Manufacturing
Biologic Pharmaceuticals
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Water Quality
Consumer Products

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