Press Releases

Spheryx Presents at the 98th ACS Colloid and Surface Science Symposium

Spheryx will be presenting a poster and an oral presentation on the use of xSight in the characterization of surfactants for applications in biologic pharmaceuticals at the ACS Colloids Symposium at the University of Washington in Seattle, from June 23-26, 2024.

New York, NY – Spheryx CEO Dr. Laura Philips will be a speaker at the 98th ACS Colloid and Surface Science Symposium. She will be presenting a talk entitled “Detecting and Identifying Free Fatty Acid Breakdown Products of Surfactants Using Total Holographic Characterization” on June 26th at 10:00 at the Husky Union Building in technical session 7, on Biological, Bio-Inspired, and Biomimetic Colloids and Interfaces. Co-authors on the paper are Dr. Fook Chiong Cheong and Tiffany Markus. Spheryx CTO, Dr. Fook Chiong Cheong, will also be presenting a poster titled “Holographic Characterization of Aspherical Colloidal Microparticles”. The technical agenda for the meeting can be found here.

The talk will focus on xSight’s ability to monitor and accurately analyze aging surfactants and free fatty acids used in biologic pharmaceutical formulations. The degradation of surfactants can limit the shelf-life of these drugs. xSight is Spheryx’s particle characterization instrument that embodies Spheryx’s proprietary technology, Total Holographic Characterization. The poster will go in depth on the xSight and its use of Total Holographic Characterization (THC).

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the 245th Electrochemical Society Meeting

Spheryx will make an oral presentation on the use of xSight in the characterization of CMP nanoparticle slurries for applications in semiconductor processing at the 245th Electrochemical Society Meeting at the Marriott Marquis in San Francisco, from May 26-30, 2024.

New York, NY – Spheryx CEO Dr. Laura Philips will be a speaker at the 245th Electrochemical Society Meeting. She will be presenting a talk entitled “Total Holographic Characterization of Large Particle Contaminants in Chemical Mechanical Polishing (CMP) Slurries” on May 27th at 4:40 at the Marriott Marquis in session D01, on Chemical Mechanical Polishing. Co-author on the paper is Dr. Fook Chiong Cheong, Chief Technology Officer at Spheryx. The technical agenda for the meeting can be found here.

The talk will focus on xSight’s ability to monitor and accurately analyze CMP nanoparticle slurries under a variety of conditions, including measurements of agglomerates and polishing pad debris. xSight is Spheryx’s particle characterization instrument that embodies Spheryx’s proprietary technology, Total Holographic Characterization.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Welcomes Dr. Kevin Dahl as Director of Technical Operations & Sales

Dr. Kevin Dahl comes to Spheryx with a wealth of experience in analytical instrumentation to be our new Director of Technical Operations and Sales.

New York, NY – Spheryx Inc. is pleased to announce that Kevin Dahl, PhD, will be joining Spheryx as Director of Technical Operations and Sales. Kevin joins Spheryx with deep experience in analytical instrumentation. Kevin holds a PhD in Chemistry, a Post-Doc at the US Naval Research Laboratory and spent 10 years with Malvern Panalytical, one of the preeminent analytical instruments companies internationally. At Malvern he was an expert on microspectroscopy and light scattering with an emphasis on bioscience applications. After Malvern, Kevin spent 6 years building the Particle Characterization Core at KBI Biopharma, a premiere analytical services company based in Colorado. Two years ago he founded Particlese, a consultancy specializing in pharmaceutical particulates.

Spheryx CEO Laura Philips shared, “We are thrilled to have Kevin join the Spheryx team. His background extends our expertise in particle characterization and its applications. He has already hit the ground running.” Dr. Dahl adds, “Spheryx is a perfect fit for me. I am excited to be joining the company at a time where Spheryx’s Total Holographic Characterization is becoming an established technology in applications in biologic pharmaceuticals and semiconductors, and I look forward to the growth in these as well as other new markets.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the 5th Engineering Cosmetics and Consumer Products Conference

Spheryx will make a featured presentation on the use of xSight in the characterization of biodegradable particles for applications in cosmetic products at the 5th Engineering Cosmetics and Consumer Products Conference at Le Méridien Philadelphia in Philadelphia, April 22-24, 2024.

New York, NY – Spheryx CEO Dr. Laura Philips will be a featured speaker at the 5th Engineering Cosmetics and Consumer Products Conference. She will be presenting a talk entitled “Holographic Characterization of Biodegradable Poly Lactic-Co-Glycolic Acid (PLGA) Microbeads for Applications in Cosmetics” on April 23 at 11:10 am at Le Méridien Philadelphia in the session on Engineering Solutions for Sustainable Development. Co-authors on the paper are Dr. Fook Chiong Cheong, Juliana Lumer, and Tiffany Markus, all from Spheryx. The technical agenda can be found here.

xSight is Spheryx’s particle characterization instrument that embodies Spheryx’s proprietary technology, Total Holographic Characterization. The talk will focus on xSight’s ability to monitor FDA approved biodegradable microbeads under a variety of conditions varying pH and temperature. The desire for sustainable products requires effective substitutes for the plastic microbeads currently used in cosmetic products. xSight can be used to validate the performance of biodegradable candidates to meet this need.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the Biotherapeutics and Vaccines Development Gordon Research Conference

March 14, 2024 - Dr. Laura Philips, CEO of Spheryx, will be presenting a poster entitled "Monitoring PS80 Degradation Products using Total Holographic Characterization" at the Biotherapeutics and Vaccines Development Gordon Research Conference. The poster presents work demonstrating the ability of Spheryx s xSight to monitor the degradation of biologic pharmaceuticals by detecting breakdown products of the surfactant used in the majority of biologic pharmaceuticals. The work further shows how xSight can distinguish multiple different contaminants simultaneously, including particles and emulsion droplets, even when they are the same size, with industry-leading accuracy and sensitivity.

The conference takes place in Galveston, TX, March 17-22, 2024 at the Grand Galvez. The poster is #22 and will be presented Wednesday and Thursday from 4-6 pm CDT.

Gordon Research Conferences provide an international forum for the presentation and discussion of frontier research in the biological, chemical, physical and engineering sciences and their interfaces.

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx’s xSight and xStream at IFPAC –2024 Advanced Manufacturing Science & Innovation Conference

Spheryx will demonstrate xSight particle characterization instrument and xStream automated sample-loader at the annual IFPAC conference at the Bethesda North Marriott, Bethesda, MD, March 3-6, 2024

February 29, 2024 - Spheryx will demonstrate xSight and xStream in Booth 505 during the Exhibition at IFPAC – 2024 Advanced Manufacturing Science & Innovation Conference. The conference will take place March 3-6 at the Bethesda North Marriott. In addition, Spheryx CEO Dr. Laura Philips will present a talk entitled “Detecting, Identifying and Quantifying Sub-Visible Particles in Biologics with Total Holographic Characterization”. Co-authors on the paper are Dr. Fook Chiong Cheong, Juliana Lumer, and Tiffany Markus, all from Spheryx. The talk will take place Wednesday, March 6 at 1:30 in the Forest Glen Room.

xSight is Spheryx’s particle characterization instrument that embodies Spheryx’s proprietary technology, Total Holographic Characterization. xStream is the companion robotic system that automates sample delivery and measurement, enabling total walk-away capability for xSight implementation. xSight Compliant Software Suite enables operation that meets all of the FDA requirements for CFR 21 Part 11 compliance. The demonstration at IFPAC will include a model custom user interface designed to meet the needs of manufacturing.

The demonstration will show xSight’s unique capability to distinguish, identify and count multiple different contaminants in biologic pharmaceutical formulations simultaneously, even when they are the same size. In addition to size and composition, xSight also delivers information about the shape of contaminant particles, including protein aggregates, silicone oil, free fatty acids, metal particles, and air bubbles.

IFPAC continues to set precedence as a forum for insightful discussions on the latest trends and real-life applications in the fields of Quality by Design, Process Analytical Technology, Emerging Technologies, Quality Metrics, Continuous Manufacturing and Process Control applications for the pharmaceutical, biotechnology, generic, chemical, petrochemical, food, and related industries.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Announces xSight Compliant Software Suite fully compliant with FDA Regulatory Requirements for GMP Environments

FDA CFR 21 Part 11 compliant software is now available for Spheryx’s xSight, a particle characterization instrument based on Total Holographic Characterization

February 21, 2024 - Spheryx announces xSight Compliant Software Suite. This new software product makes xSight fully compliant with CFR 21 Part 11, the US federal regulation specifying FDA guidelines for electronic records and signatures to implement controls that ensure the integrity of data, results and documents. xSight is now available with standard software (xSight Standard Software Suite) or with the new software (xSight Compliant Software Suite).

xSight is known for its unique ability to evaluate sub-visible particle concentration and composition, in complex samples containing multiple different particles types, using the particle index of refraction and particle shape. xSight has been deployed in a variety of formulation and metrology R&D laboratories in the pharmaceutical industry. This new regulatory compliance opens new applications for xSight in quality and manufacturing environments in the pharmaceutical industry where particle concentration is a key quality attribute.

More information about xSight Compliant Software Suite can be found here.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Degradation of Biologic Pharmaceuticals in The International Journal of Pharmaceutics

January 25, 2024 - Spheryx is pleased to announce the publication of an article in the peer-reviewed International Journal of Pharmaceutics titled “Monitoring Polysorbate 80 Degradation in Protein Solutions Using Total Holographic Characterization” by Tiffany Markus, Juliana Lumer, Rivka Stasavage, David Ruffner, Laura Philips, and Fook Chiong Cheong, all of Spheryx.

Biologic pharmaceuticals require surfactants to prevent the formation of dangerous protein aggregates. If surfactants degrade as a result of aging, or storage and handling, the safety of the drug can be compromised. This work demonstrates how Spheryx’s xSight, can monitor degradation of the surfactant, polysorbate 80 by the use of Total Holographic Characterization. The work further shows how xSight can distinguish multiple different contaminants simultaneously, including particles and emulsion droplets, even when they are the same size.

Read the paper here: https://www.sciencedirect.com/science/article/pii/S0378517324000772?via%3Dihub

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at the 23rd Annual PepTalk in San Diego, CA

January 16, 2024 - Spheryx will be presenting a poster at the 23rd annual PepTalk, which takes place from January 16th to 19th in San Diego, CA. Dr. Laura Philips, Spheryx's President & CEO, will be presenting "Detecting and Identifying Free Fatty Acid Breakdown Products of Surfectants Using Total Holographic Characterization," co-authored by Fook Chiong Cheong, Tiffany Markus, and Juliana Lumer, at the Hilton San Diego Bayfront. She will be presenting poster #B31 during Poster Session B, which takes place on Thursday and Friday. This presentation will highlight the ability of Spheryx's xSight to identify and quantify breakdown products of biopharmaceuticals that limit shelf-life. A copy of the poster can be seen below.

xSight's unique ability to determine the composition and concentrations of multiple components in complex mixtures, even when they are the same size, has been successfully applied to detect free fatty acid breakdown products of the surfectants that stabilize biologics. This presentation will demonstrate how free fatty acids are distinguished from other common contaminants such as protein aggregates and silicone oil emulsion droplets. Evidence will be presented showing that the presence of free fatty acids stimulate the formation of dangerous protein aggregates.

Conference Program: https://www.chi-peptalk.com/protein-aggregation

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at PEGS Europe, the Protein & Antibody Engineering Summit in Lisbon, Portugal, from November 14-16, 2023

November 13, 2023 - Dr. Laura Philips, CEO of Spheryx, will be presenting a poster titled “Detecting and Identifying Free Fatty Acid with Total Holographic Characterization” at PEGS Europe in Lisbon, Portugal. The conference will take place from November 14th to 16th at the Lisbon Congress Center. Laura will present results that demonstrate how Spheryx’s xSight can detect free fatty acid degradation products in biologic pharmaceuticals, a key quality indicator. Additional authors of the poster are Fook Chiong Cheong, Juliana Lumer, Tiffany Markus, and Rivka Stasavage of Spheryx, Inc. A copy of the poster can be found below.

Conference Program: https://www.pegsummiteurope.com/protein-stability

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present a Joint Paper with Applied Materials at The International Conference on Planarization Technology in Kanazawa, Japan, Oct. 31 - Nov. 2, 2023

October 30, 2023 - Dr. Laura Philips, CEO of Spheryx, will be presenting the paper “Quantitative measurement of pad debris in CMP slurries with Holographic Characterization” at the International Conference on Planarization Technology in Kanazawa, Japan. The conference takes place from October 31st to November 2nd at the Kanazawa Tokyu Hotel, and Dr. Philips will be presenting there on October 31st at 3:15pm JST. This paper presents work conducted collaboratively with Applied Materials. Additional authors of the paper are Fook Cheong, Juliana Lumer, and Tiffany Markus of Spheryx, and Yongneng Wu, Nai-Chieh Huang, Max Gage, and Jianshe Tang of Applied Materials.

The paper demonstrates how Total Holographic Characterization can detect and distinguish different types of large particle contaminants in the polishing slurries used by the semiconductor industry. Debris from the polishing pads and agglomerates of the polishing slurry can interfere with the manufacturing process and create defects on the surfaces of the semiconductor wafers, so Spheryx’s xSight is able to distinguish and quantify these different types of contaminants.

Conference Program: https://www.icpt2023.org/program.html

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at the 15th Annual Bioprocessing Summit in Boston, MA

August 8, 2023 - Spheryx will be presenting a poster at the 15th annual Bioprocessing Summit, which takes place from August 14th to 17th in Boston, MA. Dr. Laura Philips, Spheryx’s President & CEO, will be presenting the poster “Detecting and Identifying Free Fatty Acids with Total Holographic Characterization” during poster session A (#A43) from Monday, August 14th to Tuesday, August 15th at the Sheraton Boston Hotel. This presentation will highlight the ability of Spheryx’s xSight to identify and quantify breakdown products of biopharmaceuticals that limit shelf-life.

xSight’s unique ability to determine the composition and concentrations of multiple components in complex mixtures, even when they are the same size, has been successfully applied to detect free fatty acid breakdown products of the surfactants that stabilize biologics. This presentation will demonstrate how free fatty acids are distinguished from other common contaminants such as protein aggregates and silicone oil emulsion droplets. Evidence will be presented showing that the presence of free fatty acids stimulate the formation of dangerous protein aggregates.

Conference Program: https://www.bioprocessingsummit.com/stability-biologics

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Evaluation of xSight in the European Journal of Pharmaceutics and Biopharmaceutics

August 2, 2023 - We wanted to let you know about a recent publication in the European Journal of Pharmaceutics and Biopharmaceutics entitled: “Screening Techniques for Monitoring the Sub-visible Particle Formation of Free Fatty Acids in Biopharmaceuticals” by Wei Chen, Denis Klemm, Kathrin Gregoritza, Ravuri Satya Krishna Kishore, Jan Olaf Stracke, Christine Worth, Cosimo Pinto and Nuria Sancho Oltra of F. Hoffmann-La Roche AG, Basel, Switzerland.

You can find the article here.

We were happy to see the results that compare Spheryx’s xSight, using Total Holographic Characterization, to other technologies.

From the article abstract:

“In this study, we examined the feasibility of Raman microscopy, backgrounded membrane imaging (BMI) and total holographic characterization (THC) on the detection of FFA sub-visible particles (SVPs). The results indicate that THC is the most sensitive technique to track their occurrence during the course of PS hydrolysis. Moreover, with this technique we are able to distinguish different stages of FFA particle formation in the medium.”

If you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight, please contact us.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at 2023 COINS Conference at University of Pennsylvania

June 26, 2023 - Spheryx will be presenting at the 2023 Colloid and Interface Symposium (COINS). The presentation will highlight the ability of Spheryx’s xSight to identify and quantify breakdown products of biologic pharmaceuticals that limit shelf-life.

xSight’s unique ability to determine the composition and concentrations of multiple components in complex mixtures, even when they are the same size, has been successfully applied to detect free fatty acid breakdown products of the surfactants that stabilize biologics. The presentation demonstrates how free fatty acids are distinguished from other common contaminants such as protein aggregates and silicone oil emulsion droplets. Evidence will be presented showing that the presence of free fatty acids stimulates the formation of dangerous protein aggregates.

Dr. Fook Chiong Cheong, Spheryx Chief Technology, will be presenting a poster entitled “Detecting and Identifying Free Fatty Acids with Holographic Particle Characterization” on Monday, June 26 at 2:45 at the Singh Center for Nanotechnology at the University of Pennsylvania, Philadelphia, PA. The technical program for the conference can be found here.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at American Chemical Society Colloids and Surface Science Symposium

Spheryx will be making two presentations at the American Chemical Society Colloid and Surface Science Symposium on June 4-7 at North Carolina State University in Raleigh, NC. The presentations will highlight the ability of Spheryx’s xSight to address critical challenges across multiple industries, including biologic pharmaceuticals and cosmetics.

xSight’s unique ability to determine the composition and concentrations of multiple components in complex mixtures, even when they are the same size, has been successfully applied to monitor the breakdown of excipients that limit the shelf-life of biologic pharmaceuticals, and to quantitatively identify multiple emulsions and particles in complex cosmetics.

Dr. Fook Cheong, Spheryx Chief Technology Officer, will be presenting a poster entitled “Simultaneous Analysis of Multiple Colloidal Components in Complex Cosmetics Using Total Holographic Characterization” on Monday evening, June 5 (see below), and Dr. Laura Philips, Spheryx President and CEO, will be making an oral presentation entitled “Detecting and Identifying Free Fatty Acid Breakdown Products of Surfactants Using Total Holographic Characterization” on Tuesday, June 6 at 1:40 pm. The technical program for the conference can be found here.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at Center for Advanced Materials Processing Conference

Spheryx will be presenting at the Clarkson University Center for Advanced Materials Processing (CAMP) Annual Technical Meeting on May 31-June 1 in Corning, NY. The presentation will highlight the ability of Spheryx’s xSight to detect, distinguish and quantify multiple types of large particle contaminants in high-performance polishing slurries. In addition to Spheryx, other advanced materials companies will be making presentations including Corning, Estée Lauder, Global Foundries, and Bausch & Lomb.


Dr. Laura Philips, Spheryx President and CEO, will be presenting a paper entitled
“Holographic Particle Characterization of Large Particle Agglomerates in Chemical Mechanical Polishing (CMP) Slurries” on Wednesday, May 31 at the Radisson Hotel in Corning, NY. The technical program for the conference can be found here.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presenting at Cosmetics and Consumer Products Conference

Spheryx will be presenting at the American Institute of Chemical Engineers 4th Engineering Cosmetic and Consumer Product Conference, on April 20. The presentation will highlight the ability of Spheryx’s xSight to detect, distinguish and quantify multiple, different emulsions and colloidal particles simultaneously in complex cosmetic products.

xSight’s unique ability to determine the composition and concentrations of multiple components in complex mixtures, even when they are the same size, has been successfully applied to challenges in the biologic pharmaceuticals industry and to CMP slurries from the semiconductor industry. Spheryx is exploring applications of our Total Holographic Characterization technology in the cosmetics industry.

Dr. Laura Philips, Spheryx President and CEO, will be presenting a paper entitled
“Simultaneous Analysis of Multiple Colloidal Components in Complex Cosmetics Using Total Holographic Characterization” on Thursday, April 20 at 11:55 at the Crowne Plaza Princeton Conference Center, Plainsboro, New Jersey. The technical program for the conference can be found here.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Explore xSight's User-Friendly Interface

We are proud of how popular our xSight User Interface is with our customers. The feedback has been so positive that we want to share the user experience with our prospective customers and friends.

xSight is Spheryx’s particle characterization instrument that deploys our proprietary Total Holographic Characterization® technology to measure particle size, composition, shape, and concentration in complex mixtures of different types of particles, even when they are the same size.

We have created a new page on our website to give you a sense of how easy xSight is to use, and the many different ways users can explore their data and results. Please check it out here.

Please contact us if you would like to know more about Spheryx’s proprietary technology Total Holographic Characterization® as embodied in xSight.

Laura Philips, CEO
lphilips@spheryx.solutions


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

We wanted to let you know about a recent publication in the Journal of Pharmaceutical Sciences entitled "The Strengths of Total Holographic Video Microscopy in detecting sub-visible protein particles in Biopharmaceuticals: A comparison to Flow Imaging and Resonant Measurement" by Harri Rahn, Merve Oeztuerk, Nikolai Hentz, Friedrike Junge and Markus Hollmann of AbbVie Deutschland GmbH & Co.

You can find the article here: https://www.sciencedirect.com/science/article/pii/S002235492200613X?dgcid=author

Please contact us if you would like to know more about Spheryx s proprietary technology Total Holographic Characterization® as embodied in xSight.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at 2022 PEGS Europe Conference
and Announces Additions to the Leadership Team

Spheryx will make a poster presentation November 15 in Barcelona, Spain at the 2022 PEGS Europe Conference

New York, NY – Spheryx announces a poster presentation entitled “Detecting and Identifying Free Fatty Acid Breakdown Products of Surfactants Using Total Holographic Characterization” delivered by Dr. Laura Philips, Spheryx President and CEO, on November 15 at the 2022 PEGS Europe Conference. PEGS Europe is a 3-day event that draws international participants interested in collaborating and sharing best practices in the areas of protein and antibody engineering, oncology, expression, analysis, immunogenicity, and therapeutics.

The poster attached below demonstrates the ability of Spheryx’s xSight to identify contaminants in protein solutions. Beyond particle size, xSight measures the refractive index and the shape of particle contaminants to identify their composition. The poster presents measurements of free fatty acids compared to breakdown products of surfactants, and distinguishes these breakdown products from other contaminants such as silicone oil and protein aggregates. These results demonstrate xSight’s ability to detect early signs of surfactant aging, which may limit the shelf-life of biologic pharmaceuticals. The co-authors of the poster are Ms. Juliana Lumer, Ms. Tiffany Markus and Dr. Fook Chiong Cheong, all of Spheryx.

Spheryx also announces two additions to the leadership team, Mike Dolence, Controller, and Catherine Noden, Manager, Administration. Their bios can be found on our website leadership page.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx’s xSight and xStream at AAPS PharmSci 360

Spheryx will demonstrate xSight, their particle characterization instrument, and xStream, their automated sample-loader, at the annual AAPS PharmSci 360 conference at the Boston Convention & Exhibition Center October 16-19.

October 13, 2022 - New York, NY – Spheryx will continuously demonstrate xSight and xStream in Booth 858 at the Exhibition of the American Association of Pharmaceutical Scientists 2022 PharmSci 360 Conference. The conference will take place from October 16-19, 2022 at the Boston Convention & Exhibition Center in Boston, MA.

xSight is Spheryx’s particle characterization instrument that embodies Spheryx’s proprietary technology, Total Holographic Characterization. xStream is the companion robotic system that automates sample delivery and measurement, enabling total walk-away capability for xSight implementation.

The demonstration will show xSight’s unique capability to distinguish, identify and count multiple different contaminants in biologic pharmaceutical formulations simultaneously, even when they are the same size. In addition to size and composition, xSight also delivers information about the shape of contaminant particles, including protein aggregates, silicone oil, free fatty acids, metal particles, and air bubbles.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents Papers on Detection of Large Particle Contaminants in CMP Slurries at International Conference on Planarization/CMP Technology 2022

Spheryx delivers an oral and a poster presentation demonstrating the capabilities of Total Holographic Characterization® for quantitatively detecting large particle contaminants in chemical mechanical planarization slurries at ICPT 2022 in Portland, Oregon.

New York, NY – Spheryx announces the presentation of a paper entitled “Measuring Large Particle Contaminants in Cerium Oxide Chemical Mechanical Polishing (CMP) Slurries with Total Holographic Characterization” and a poster entitled “Holographic Characterization of KMnO4 based CMP Slurries for SiC Polishing” at the International Conference on Planarization/CMP Technology (ICPT) 2022, September 27-29 at the Benson Hotel in Portland, OR. The conference is focused on chemical mechanical planarization (CMP), one of the most important processes in semiconductor manufacturing, and draws attendees from around the world to address current challenges in the semiconductor industry. The paper will be presented by Dr. Laura Philips (President & CEO, Spheryx, Inc.) and the poster by Dr. Fook Chiong Cheong (Chief Technology Officer, Spheryx, Inc.).

The paper is co-authored by Dr. Cheong, Juliana Lumer, Hillary Gao, and Tiffany Markus all of Spheryx. The poster (attached) is co-authored by Dr. Philips, Juliana Lumer, Mary Ann Odete, Tiffany Markus, all of Spheryx, and Carlo Aparece of Mega Kinetic Fluidic Systems.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at 2022 Colorado Protein Stability Conference

Spheryx will make a poster presentation August 10 in Breckenridge, CO at the 2022 Colorado Protein Stability Conference.

New York, NY – Spheryx announces a poster presentation entitled “Detecting and Identifying Free Fatty Acid Breakdown Products of Surfactants Using Total Holographic Characterization” delivered by Dr. Laura Philips, Spheryx President and CEO, on August 10 at the 2022 Colorado Protein Stability Conference in Breckenridge, CO.

Protein stability is important in numerous disciplines, ranging from fundamental and applied protein biophysics to basic and medical biochemistry to pharmaceutical sciences. Since 1994, Colorado Protein Stability Conferences have provided unique opportunities for an exchange of information between researchers across multiple disciplines, academic institutions and industries.

The poster attached below demonstrates the ability of Spheryx’s xSight to identify contaminants in protein solutions. Beyond particle size, xSight measures the refractive index and the shape of particle contaminants to identify their composition. The poster presents measurements of free fatty acids compared to breakdown products of surfactants. It also shows the effects of different stresses on protein solutions with and without surfactant. Applied stresses include heating, freezing, and shaking. xSight distinguishes different particle composition, such as air bubbles and silicone oil droplets, by their indexes of refraction even when the particles are the same size and shape. The co-authors of the poster are Ms. Juliana Lumer, Ms. Tiffany Markus and Dr. Fook Chiong Cheong, all of Spheryx.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes New Method for Monitoring Cell Viability in Scientific Reports

Spheryx publishes a paper in “Scientific Reports” demonstrating Spheryx’s xSight’s ability to measure yeast cell viability and changes in cell structure upon cell death.

July 27, 2022 - New York, NY – Spheryx announces the publication of an article entitled “Label-free Viability Assay using In-line Holographic Video Microscopy” in the peer-reviewed journal, Scientific Reports. The article can be found here. The paper was authored by Rostislav Boltyanskiy, Mary Ann Odete, Fook C. Cheong, and Laura A. Philips, all of Spheryx.

Spheryx’s xSight was used to determine the viability of yeast cells under different stress conditions without the need for fluorescence labels. The cell index of refraction changes upon cell death, generating a characteristic change in the measurement using Spheryx’s proprietary Total Holographic Characterization® technology as embodied by xSight. Changes in the structure of the cell is also observed using xSight.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at IFPAC Annual Meeting on Process Analytical Technology for the Pharmaceutical Industry
Spheryx will present a talk on their innovative particle characterization technology and applications for quality control in pharmaceutical manufacturing at IFPAC on June 15, 2022 in Bethesda, MD.

June 14, 2022 - New York, NY – Spheryx announces a talk entitled “Quantifying Difference in Protein Aggregation in Multiple Standard Buffers and Stress Conditions” delivered by Dr. Laura Philips, Spheryx President and CEO, on June 15 in the Forest Glen Conference Room at the Marriott North Bethesda, during the Annual Meeting of IFPAC. The IFPAC Annual meeting is a forum for discussions about the latest trends in Quality by Design, Process Analytical Technology, Emerging Technologies, Quality Metrics, Continuous Manufacturing and Process Control applications for the pharmaceutical industry, featuring regulators, manufacturers, researchers and industry users.

Dr. Philips’ talk presents measurements of protein aggregation behavior as a function of different buffers and different stress conditions. The role of surfactants and free fatty acids, breakdown products of surfactants, will be discussed. Spheryx’s technology, embodied in their particle characterization instrument, xSight, has unique advantages for identifying and quantifying multiple components in complex biopharmaceutical formulations, including typical contaminants such as silicone oil, free fatty acids, air bubbles and protein aggregates. The co-authors of the presentation are Ms. Juliana Lumer, Ms. Mary Ann Odete, Dr. Rostislav Boltyanskiy, Ms. Hillary Gao, and Dr. Fook Chiong Cheong, all of Spheryx.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the European APV Workshop on Protein Aggregation and Immunogenicity

Spheryx will make a poster presentation May 31-June 1 in Eimeldingen, Germany at the APV Protein Conference.

New York, NY – Spheryx announces a poster presentation entitled “Detecting and Identifying Free Fatty Acid Breakdown Products of Surfactants Using Total Holographic Characterization” delivered by Dr. Laura Philips, Spheryx President and CEO, on May 31 and June 1 at the Annual APV Workshop on Protein Aggregation and Immunogenicity in Eimeldingen, Germany. This event will focus on biologic pharmaceuticals and the role formulation and aggregation play in immunogenicity. After a two year hiatus due to the pandemic, the Workshop will be an opportunity for the community to come together again.

The poster below demonstrates the ability of Spheryx’s xSight to identify contaminants in protein solutions. In addition to particle size, xSight measures the refractive index and the shape of particle contaminants to identify their composition. The poster presents measurements of free fatty acids compared to breakdown products of surfactants. It also shows the effects of different stresses on protein solutions with and without surfactant. Applied stresses include heating, freezing, and shaking. xSight distinguishes different particle composition, such as air bubbles and silicone oil droplets, even when the particles are the same size and shape, by their indexes of refraction. The co-authors of the poster are Ms. Juliana Lumer, Ms. Mary Ann Odete and Dr. Fook Chiong Cheong, all of Spheryx.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx and NIST Publish Results in the Journal of Pharmaceutical Sciences on Protein Aggregates in Stir Stressed NIST mAb Protein

Spheryx and NIST publish a paper on stressed NIST monoclonal antibody (mAb) protein samples using Spheryx’s xSight and other technologies to evaluate protein aggregate density in the peer-reviewed Journal of Pharmaceutical Sciences.

New York, NY – Spheryx announces the publication of an article entitled “Distribution of Average Aggregate Density from Stir-stressed NISTmAb Protein” in the peer-reviewed journal, The Journal of Pharmaceutical Science. Currently, the article can be found at DOI:https://doi.org/10.1016/j.xphs.2022.03.011. The paper was authored by Richard E. Cavicchi (NIST), Laura A. Philips (Spheryx), Fook C. Cheong (Spheryx), David B. Ruffner (Spheryx), Priya Kasimbeg (Spheryx), and Wyatt Vreeland (NIST).

Spheryx’s xSight was used to determine the density of the monoclonal antibody (mAb) aggregates and the results were found to be similar to measurements made with a fluorescent microscope. xSight is Spheryx’s particle characterization instrument which uses Spheryx’s proprietary Total Holographic Characterization® technology to analyze colloidal mixtures to determine particle size, shape, composition and concentration of multiple particle types simultaneously. Protein aggregate density is important for understanding the impact of aggregates on the performance and safety of biologic pharmaceuticals.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the 21st Annual Peptalk Conference
Spheryx will make a virtual poster presentation at Peptalk, the Protein Science and Production week, January 17-19.

New York, NY – Spheryx announces a poster presentation entitled “Size, Shape, Count and Identification of Contaminants Using Total Holographic Characterization” delivered by Dr. Laura Philips, Spheryx President and CEO, virtually on January 18 and 19. The poster demonstrates the ability of Spheryx’s xSight to identify contaminants in protein solutions. In addition to particle size, xSight measures the refractive index and the shape of particle contaminants to identify their composition. The poster below presents measurements of model solutions showing the effects of different stresses on protein solutions. Applied stresses include heating, freezing, and different methods of mixing. xSight can distinguish different particle composition, such as air bubbles and silicone oil droplets, even when the particles are the same size and shape, by their indexes of refraction. The co-authors are Dr. Rostislav Boltyanskiy, Dr. David Ruffner, Ms. Mary Ann Odete and Dr. Fook Chiong Cheong all of Spheryx.



About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

New Software Release for Spheryx’s xSight Adds Many New Features Requested by Customers

Spheryx’s new software release adds capabilities to the user interface expanding data analysis capabilities and data reporting formats.

New York, NY – Spheryx announces a new software release for xSight, its particle characterization instrument. xSight is already known for its unique ability to evaluate complex heterogeneous mixtures of particles with a user-friendly interface. The new software release includes multiple new features and incorporates customer feedback and continuous improvement.

Users can now load multiple datasets simultaneously, reducing the time and effort to review results. Multiple datasets can be plotted simultaneously to compare subtle variations between measurements. Users can also customize the automated reports to view specific regions of size and refractive index. Concentrations of multiple components of a heterogeneous mixture can be viewed as cumulative totals, which is particularly valuable for the pharmaceutical industry as per FDA requirements.

Additionally, the user interface for xStream, the robotic automated sample loader for xSight, has been streamlined to ease the transfer of sample information, further enhancing measurement of samples in 96-well plates. Also included in the new software release are enhanced noise reduction, added robustness and a variety of bug fixes.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Featured in Chemical & Engineering News

Spheryx is featured as an innovative start-up company in the November 22 issue of Chemical & Engineering News.

New York, NY – Spheryx is featured in Chemical & Engineering News (C&EN) in an article entitled “Chemistry start-ups on our radar in 2021.” The November 22, 2021 issue highlights 5 early-stage companies that are improving the world. Spheryx’s patented Total Holographic Characterization® is highlighted as a powerful tool for product development, quality assurance and environmental monitoring in industries including pharmaceuticals, semiconductor processing and wastewater quality.

C&EN is committed to keeping its readers up to date with important chemistry news. Their reporters and editors track important research advances, business and policy trends, chemical safety practices, career guidance, and more. Their journalists are based in the US, Europe, and Asia, and chemists recognize them for breaking-news coverage and award-winning features. C&EN has been published by the American Chemical Society since 1923.

Laura Philips, President & CEO of Spheryx stated “We are pleased to be featured in C&EN, a publication that serves such a diverse chemistry community across academia, industry, government, and more. It is a publication I have been reading my entire career and it is an honor for Spheryx to be recognized by them as an exciting company with innovative technology that is newsworthy for their extensive readership.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the 13th Annual Bioprocessing Summit

Spheryx will make a poster presentation at the 39th Annual Bioprocessing Summit, August 18-19, in Boston, MA.

New York, NY – Spheryx announces a poster presentation entitled “Size, Shape, Count and Identification of Contaminants Using Total Holographic Characterization” delivered by Dr. Laura Philips, Spheryx President and CEO, on August 18 and 19, 2021 in the Exhibit Hall at the Boston Sheraton. The co-authors are Dr. Rostislav Boltyanskiy, Dr. David Ruffner, Ms. Mary Ann Odete and Dr. Fook Chiong Cheong all of Spheryx. A copy of the poster is below.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the American Chemical Society 95th Annual Colloid and Surface Science Symposium

Spheryx will make two presentations at the Virtual ACS Colloids and Surface Science Symposium on June 14-16.

New York, NY – Spheryx announces the presentation of two papers at the American Chemical Society 95th Annual Colloid and Surface Science Virtual Symposium. Dr. Rostislav Boltyanskiy, Spheryx Senior Scientist, will deliver a presentation entitled “Detecting and distinguishing particles in heterogeneous colloidal mixtures by size, refractive index and symmetry with Total Holographic Characterization” on June 14 at 3:20 (EDT) and Dr. Laura Philips, Spheryx President and CEO, will deliver a second presentation entitled "Quantitative, Label-Free Yeast Cell Viability Determination Using Total Holographic Characterization” on June 16 at 3:40 (EDT).

The conference has a long tradition of bringing together academic and industrial researchers from across the globe with common interests in colloidal systems, interfacial phenomena and soft matter topics.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the Chemical Mechanical Polishing User Group Virtual Conference

On April 22, 2021, Spheryx will present results of testing cerium oxide semiconductor polishing slurries without the need for dilution or special sample preparation, demonstrating the advantages of Spheryx’s technology in monitoring the quality of polishing slurries.

New York, NY – Spheryx will make a presentation entitled “Measuring Large Particle Contaminants in Cerium Oxide Chemical Mechanical Polishing (CMP) Slurries with Total Holographic Characterization” at the virtual Chemical Mechanical Polishing User Group (CMPUG) Conference on April 22, 2021. The presentation will highlight the ability of xSight, Spheryx’s particle characterization instrument that leverages proprietary Total Holographic Characterization® technology, to effectively monitor CMP slurry quality in 30 nm cerium oxide slurries. xSight is able to measure large particle contaminants in these slurries under conditions typically deployed in semiconductor manufacturing, without the need for dilution or special sample preparation, making direct measurements during manufacturing possible.

CMPUG was formed to explore the issues and challenges associated with CMP, a rapidly growing technology in the semiconductor industry. CMPUG’s conferences include presentations on topics of interest to the CMP community. CMP is used for planarization and surface finishing in the manufacture of silicon wafers, integrated circuits (IC’s), magnetic heads and micro-electromechanical devices (MEMS). CMP is recognized as the premiere method for achieving ultraflat and ultrasmooth surfaces when they are most critical, thus enabling many of the advanced electronic devices currently in production.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

New Software Release for Spheryx’s xSight Increases Particle Characterization Measurement Speed by 20%

Spheryx’s new software release reduces the time it takes for xSight to characterize particles by 20% as measured from the time the user pushes “start” until the analysis is complete.

New York, NY – Spheryx announces a new software release for xSight, its particle characterization instrument. xSight is known for its unique ability to evaluate complex heterogeneous mixtures of particles using the particle index of refraction. The new software release reduces measurement time by 20% on a standard sample of silicone oil and protein aggregates at concentrations of 10⁵ particles/mL. Particle measurement time is measured from the time the user presses start until the analysis is complete. This standard sample has a wide range of particle sizes (500 nm to 10 µm), and different particle types (spherical and irregularly shaped particles), and is in the mid-range of concentrations (10⁴ – 10⁶ particles/mL) measured by Spheryx’s xSight. The improvement is dependent on the type of particles in the sample and the concentration of particles. Samples with higher concentrations can see a larger reduction in measurement time, some as much as 50%. Also included in the new software release is enhanced noise reduction which is particularly important for sensitive detection of small particles. Improvements in speed and sensitivity will enhance efficiency for applications in biologic pharmaceuticals and semiconductor slurries, as well as other industrial and research applications.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

New Software Release for Spheryx’s xSight, its Particle Characterization Instrument, Delivers a 4th Dimension of Information

Spheryx adds particle symmetry to particle size, particle composition and particle concentration in their new software release that enhances xSight.

New York, NY – Spheryx announces a new release of software for xSight, its particle characterization instrument. xSight is known for its unique ability to evaluate particle composition in complex samples containing multiple different particles types using the particle index of refraction. Spheryx’s new software release adds another dimension of information to results provided by xSight: particle symmetry. With this release xSight delivers four dimensions of information about particles in the critical size range of 500 nm to 10 µm: size, composition, concentration and symmetry. All of these parameters can be determined simultaneously for multiple particle types, even when they are the same size. This capability has immediate application in the biologic pharmaceutical industry where the ability to distinguish symmetric inert emulsion droplets from irregularly shaped and dangerous protein aggregates is of paramount importance. In many other industries, particle characterization is enhanced by knowledge about the particle shape as well.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Collaborates with NYU on Submission for XPRIZE Award for COVID-19 Diagnostic Based on Spheryx’s xSight

Spheryx has joined with New York University-based Team, HolographicDiagnostics, to submit an application for an XPRIZE award to develop a commercial COVID-19 diagnostic utilizing Spheryx’s proprietary particle characterization technology.

New York, NY – Spheryx and New York University (NYU) are collaborating on Team HolographicDiagnostics to submit a proposal for the XPRIZE Rapid COVID Testing Award. The Award is a $5 million dollar, 6-month competition to develop faster, cheaper, and easier to use COVID-19 testing methods at scale. The team administrators are Prof. David Grier, NYU Professor of Physics and Spheryx co-founder, Prof. Kent Kirshenbaum, NYU Professor of Chemistry, and Dr. Laura Philips, Spheryx President, CEO and co-founder. The proposal utilized Spheryx’s xSight, a revolutionary particle characterization instrument with the sensitivity, accuracy and precision required to detect virus particles or antibodies in patient samples by watching them bind to the surface of specifically functionalized colloidal beads. Dr. Philips stated “It is an honor for Spheryx to participate in an effort that can have an immediate impact on assessing infection and improving the quality of life for everyone during the pandemic. Everyone at Spheryx is excited about the opportunity to use Spheryx’s unique capabilities to create a whole new category of medical diagnostics to be used in the battle with COVID-19 as well as a host of other diseases.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Make a Joint Presentation with Mega Fluid Systems at the Chemical Mechanical Polishing User Group Virtual Conference

Spheryx will present with Mega Fluid Systems on September 1, demonstrating the advantages of Spheryx’s technology in monitoring the quality of polishing slurries.
 
New York, NY – Spheryx announces an oral presentation at the virtual Chemical Mechanical Polishing User Group (CMPUG) Conference entitled “Effective Slurry Mixing and Handling and its Impact on CMP Slurry Particle Health” on September 1, 2020. The presentation will be a joint presentation between Spheryx and Mega Fluid Systems delivered by Carlo Aparece of Mega Fluid Systems and Laura Philips, Spheryx President and CEO. The co-authors are Koh Murai of Mega Fluid Systems and Fook Chiong Cheong of Spheryx. The presentation will highlight the ability of Spheryx’s Total Holographic Characterization®, embodied in xSight, Spheryx’s particle characterization instrument, to effectively monitor CMP slurry quality. Chemical Mechanical Polishing (CMP) is a technology used for planarization and surface finishing in the manufacture of silicon wafers, integrated circuits (IC’s), magnetic heads and micro-electromechanical devices (MEMS). CMP is recognized as the premiere method for achieving ultraflat and ultrasmooth surfaces when they are most critical, thus enabling many of the advanced electronic devices currently in production. The CMP Users Group (CMPUG) was formed to explore the issues and challenges associated with this fast-growing technology. The CMPUG’s main activity is a quarterly meeting with technical presentations on topics of interest to the CMP community.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at PEGS Boston VIRTUAL, Aug. 31 through Sept. 4, 2020

Spheryx will have a virtual booth and make a poster presentation at the 16th Annual PEGS Boston Conference (Aug. 31-Sept. 4), which will take place virtually for the first time.

New York, NY – Spheryx announces a poster presentation at the PEGS Boston VIRTUAL Conference entitled “Using Hologram Symmetry in Addition to Refractive Index to Distinguish Particles using Total Holographic Characterization®,” delivered by Dr. Laura Philips, Spheryx President and CEO. The co-authors are Dr. Rostislav Boltyanskiy, Dr. Fook Chiong Cheong, and Ms. Hillary Gao. Spheryx will be exhibiting throughout the conference in a virtual booth, featuring streaming demonstrations of xSight, Spheryx’s particle characterization instrument, xStream, a robotic sample loader for xSight, and xCell, custom disposable microfluidic sample chips. Dr. Philips and Dr. Cheong, Spheryx CTO, will be available in the virtual booth to discuss Spheryx technology and answer questions. Materials will also be available for download.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Protein Aggregates and Other Biopharmaceutical Contaminants in the Journal of Pharmaceutical Sciences

Spheryx publishes a paper demonstrating the capabilities of Spheryx’s product, xSight, to distinguish protein aggregates from multiple other typical biopharmaceutical contaminants in viscous mixtures in the peer-reviewed Journal of Pharmaceutical Sciences.

New York, NY – Spheryx announces the publication of an article entitled “Quantitative differentiation of protein aggregates from other sub-visible particles in viscous mixtures through holographic characterization” in the peer-reviewed journal, The Journal of Pharmaceutical Science. Currently, the article can be found at https://doi.org/10.1016/j.xphs.2020.05.002.The paper was authored by Annemarie Winters, Fook C. Cheong, Mary Ann Odete, Juliana Lumer, David B. Ruffner, Kimberly Mishra, and Laura A. Philips, all of Spheryx and Prof. David G. Grier of New York University.

The paper demonstrates the advantages of Spheryx’s proprietary technology deployed in Spheryx’s particle characterization instrument, xSight, for analyzing model biologic pharmaceutical formulations in the presence of common contaminants. The paper discusses how Spheryx’s technology clearly distinguishes different species of sub-visible particles and determines each population’s concentration accurately in viscous mixtures, including protein aggregates, silicone oil, metal particles, air bubbles and fatty acids, breakdown products of surfactants.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Awarded Phase IIB NIH SBIR Grant to Support the Development of Total Holographic Characterization® for Biologic Pharmaceutical Applications

Spheryx, Inc. was awarded a Phase IIB Small Business Innovation Research grant by the National Institutes of Health to support the development of their Total Holographic Characterization® for applications in the pharmaceutical industry, particularly protein-based pharmaceuticals.

New York, NY – Spheryx, Inc. announced today that the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) has awarded the company a Phase IIB Small Business Innovation Research (SBIR) grant for $2,000,000 over 2 years. This new grant is a continuation of an earlier grant entitled “Instrument for Characterization of Protein Aggregates” and will support further development of Spheryx’s proprietary Total Holographic Characterization® technology. These highly competitive grants are intended to stimulate technological innovation and commercialization for small businesses.

Previous funding from Phases I and II of this SBIR grant resulted in two publications in the Journal of Pharmaceutical Sciences (here, here), demonstrating the capabilities of Spheryx’s technology to monitor contaminants in biologic products, with Spheryx’s first particle characterization product, xSight.

Dr. Laura Philips, Spheryx Founder, President and CEO, commented, “This Phase IIB SBIR grant will enable us to enhance the capabilities of our technology in direct response to feedback from the pharmaceutical industry. These enhancements will enable our products to meet the needs of quality control and manufacturing process control to increase biologic product safety for consumers while also decreasing costs of product development and manufacturing. We are pleased that this grant further validates the promise of our technology for meeting the needs of the biologics industry.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the International Association for Pharmaceutical Technology Workshop on Protein Stability

Spheryx will make a poster presentation at the Association for Pharmaceutical Technology (APV) Workshop on Protein Stability, February 5-6, in Munich, Germany.

New York, NY – Spheryx announces a poster presentation entitled “Quantitative Differentiation of Protein Aggregates from Subvisible Contaminants in Viscous Mixtures Through Holographic Characterization,” delivered by Dr. Laura Philips, Spheryx President and CEO, on February 5-6, 2020, at the Maritim Hotel in Munich, Germany. The co-authors are Ms. Annemarie Winters, Ms. Mary Ann Odete, Dr. Rostislav Boltyanskiy, Dr. David Ruffner, and Dr. Fook Chiong Cheong, all from Spheryx.

The workshop, held under the auspices of APV (www.apv-mainz.de), gathers opinion leaders from around the world involved in the development and manufacture of therapeutic proteins. The focus of the APV workshop is protein stability challenges encountered during the development of protein-based pharmaceuticals, with analytical methods for detecting protein aggregates and other degraded species one of the main topics of the workshop. Spheryx’s presentation focuses on the unique capabilities of xSight, their proprietary particle characterization instrument, to detect, count and identify multiple contaminants simultaneously.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the 19th Annual PepTalk, The Protein Science Week

Spheryx will have a booth and make a poster presentation at the 19th Annual PepTalk Conference, January 20-24, in San Diego, CA.

New York, NY – Spheryx announces a poster presentation entitled “Quantitative Differentiation of Protein Aggregates from Subvisible Contaminants in Viscous Mixtures Through Holographic Characterization,” delivered by Dr. Laura Philips, Spheryx President and CEO, on January 23, 2020, in the Sapphire Ballroom of the Hilton San Diego Bayfront. The co-authors are Ms. Annemarie Winters, Ms. Mary Ann Odete and Dr. Fook Chiong Cheong, all of Spheryx. Spheryx be exhibiting throughout the conference in Booth 425, featuring xSight, Spheryx’s particle characterization instrument, xStream, a robotic sample loader for xSight, and xCell, custom disposable microfluidic sample chips.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Porous Colloids in Soft Matter and Presents at the Annual Meeting of the Society of Cosmetic Chemists

A paper demonstrating Spheryx’s xSight’s ability to provide new insights into complex particles has been published in the journal Soft Matter. Spheryx also announces a presentation at the Annual Meeting of the Society of Cosmetic Chemists in New York City on December 17 & 18.

New York, NY – Spheryx announces the publication of an article entitled “The role of the medium in the effective-sphere interpretation of holographic particle characterization data” in the peer-reviewed journal, Soft Matter, which can be found at https://pubs.rsc.org/en/content/articlepdf/2020/SM/C9SM01916B. The work was a collaboration of Mary Ann Odete, Fook Chiong Cheong, Annemarie Winters, and Laura A. Philips of Spheryx, Inc., Jesse J. Elliott of the University of Chicago, and Prof. David G. Grier of New York University. The paper demonstrates that Spheryx’s particle characterization instrument, xSight, provides unique insights into the structure of complex particles such as protein aggregates, nanoparticle slurry agglomerates and mesoporous spheres.

Spheryx will present results from its proprietary technology at the Annual Meeting of the Society of Cosmetic Chemists in New York City, December 17 & 18. The presentation is entitled “Simultaneous Analysis of Multiple Colloidal Components in Complex Cosmetics using Total Holographic Characterization^®.” Dr. Laura Philips, President and CEO of Spheryx, stated, “We are pleased to see that xSight is finding applications across many different industries, where the unique capabilities of our technology provide a new dimension of information to address critical unmet needs.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Co-Founder, Prof. David Grier, Named a Fellow of the National Academy of Inventors

Spheryx Co-Founder Prof. David Grier, professor of physics at New York University and inventor of Spheryx’s Total Holographic Characterization®, has been elected into the National Academy of Inventors

New York, NY – Spheryx announced today that co-founder Physics Professor David Grier has been elected to the National Academy of Inventors. Prof. Grier is a pioneer in the field of holographic video microscopy, the technology that is the foundation of Spheryx’s xSight, an innovative instrument for particle characterization. Grier is currently a Professor of Physics at New York University, a founding member of NYU’s Soft Matter Center, and the Chair of the Spheryx Scientific Advisory Board. Spheryx’s xSight has applications in quality assurance, product development, and manufacturing process control in industries including biologic pharmaceuticals, semiconductor polishing slurries, cosmetics and oil & gas.

Prof. Grier remarked, “I am honored by this recognition and delighted that Spheryx is developing our patents to create instruments that will be useful for challenges across so many industries.” Dr. Laura Philips, Spheryx’s President, CEO and co-founder stated, “We at Spheryx celebrate David’s well deserved recognition for his creative inventions. We are grateful that his inspiration birthed the technologies that led to Spheryx’s revolutionary products.”

In April, Grier will be inducted into the National Academy of Inventors at the annual National Academy of Inventors Conference in Phoenix, AZ.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the 2019 Protein Stability Conference

Spheryx will present at the 25th Anniversary Protein Stability Conference in Breckenridge, Colorado, July 29-Aug 1.

New York, NY – Spheryx is pleased to announce a presentation at the 25th Anniversary of the Protein Stability Conference. The conference is hosted by the University of Colorado Center for Pharmaceutical Biotechnology and will take place in Breckenridge, CO from July 29-Aug 1. Since 1994 the Colorado Protein Stability Conferences have provided unique opportunities for the exchange of information among members of the protein science community. The scientific sessions consist of plenary lectures by leading researchers and contributed papers presented during a poster session. To foster exchange of information among members of the field, attendance is limited to 250 registrants. Dr. Laura Philips, Spheryx President and CEO, will present a contributed paper entitled “Distinguishing Protein Aggregates from Contaminants in Viscous Mixtures with Holographic Video Microscopy” during the session on Wednesday, July 31 from 11am - 1 pm.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the American Chemical Society 93rd Annual Colloid and Surface Science Symposium

Spheryx will make two presentations at the ACS Colloids and Surface Science Symposium being held at Georgia Institute of Technology, on June 16-19.

New York, NY – Spheryx announces the presentation of two papers at the American Chemical Society 93rd Colloid & Surface Science Symposium. An oral presentation will be delivered by Dr. Laura Philips, Spheryx President and CEO, on June 17 at 2:30 entitled “Distinguishing Protein Aggregates from Contaminants in Viscous Mixtures with Holographic Video Microscopy". A poster will be presented by Dr. Rostislav Boltyanskiy, Spheryx Senior Scientist, on June 17 from 4:45-6:45 entitled “Distinguishing Rocks from Drops using Holographic Video Microscopy”. The conference has a long tradition of bringing together academic and industrial researchers from across the globe with common interests in colloidal systems, interfacial phenomena and soft matter topics and will take place at the Georgia Tech Conference Center in Atlanta, Georgia.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Selected by NIH to Present at BIO 2019 and will also Present at Electrochemical Society Meeting

- Spheryx selected as one of 80 NIH SBIR grantees to showcase the most promising and transformational innovations at BIO 2019, June 3-6 in Philadelphia
- Dr. Laura Philips, President and CEO, Spheryx, Inc., will present at BIO 2019, June 5, one of 12 NIH selected presenters
- Dr. Fook Chiong Cheong, CTO, Spheryx, Inc., to present at the Electrochemical Society meeting, May 28 in Dallas 

New York, NY –  Spheryx, Inc. was selected by National Institutes of Health (NIH) and BIO to showcase its technology at BIO 2019, June 3-7, 2019, in Philadelphia, PA. Spheryx will be featured in the Innovation Zone (IZ-44 in Booth #4270), a showcase for the top 80 NIH SBIR-funded companies pushing the boundaries of scientific innovation for advancements in human health. The BIO International Convention is the largest global event for the biotechnology industry, attracting over 16,000 biotech leaders from 67 countries.

 
Spheryx was one of only twelve companies chosen to pitch their innovative technology in a featured presentation at BIO 2019. Dr. Laura Philips, President and CEO of Spheryx, will present on Wednesday, June 5, at 11:45 am in Theatre 4. Dr Philips commented, “We are delighted for this high-profile opportunity to showcase Spheryx’s xSight, our revolutionary particle characterization instrument, and grateful for NIH support through an SBIR Phase II grant.”

 
Dr. Fook Chiong Cheong CTO, Spheryx, Inc., will present “Holographic Characterization of Contaminants in CMP Slurries” at the Electrochemical Society (ECS) meeting, May 28 at 11:15 am at the Dallas Sheraton Hotel - Pearl 2, where industry leaders from around the world will convene to share the latest scientific and technical developments in electrochemistry and solid-state science and technology. Dr Cheong will discuss Spheryx xSight’s unique ability to detect and determine the composition, size and concentration of several challenging large particle contaminants in CMP nanoparticle slurries, a key component in semiconductor manufacturing.

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Introduces xSight, a Revolutionary Particle Characterization Instrument, with Live Demonstrations at the 10th Annual PEGS Boston, April 8-12, 2019.

Spheryx Selected to Participate in Hello Tomorrow Global Summit, Paris

Spheryx Announces New Hire, Dr. Ross Boltyanskiy

Spheryx introduces xSight with live demonstrations at a leading international conference on protein-based therapeutics. The technology meets a critical industry need for the detection and characterization of protein aggregates, a safety hazard in biologic pharmaceuticals.

New York, NY - Spheryx, Inc. will demonstrate xSight, their particle characterization instrument, at PEGS Boston, April 8-12, 2019, in the Exhibit Hall at Seaport World Trade Center, Booth 500. PEGS Boston is the largest biologics event, drawing over 2,600 international participants interested in collaborating and sharing best practices in biologic therapeutics. xSight uses Spheryx’s proprietary technology, Total Holographic Characterization®, to detect, count and characterize sub-visible particles in complex heterogeneous mixtures, including protein aggregates, a known safety hazard in biologic pharmaceuticals.

Additionally, Spheryx was selected from 4,500 applicants to participate in the Hello Tomorrow Global Summit in Paris, an annual competition to showcase start-ups that solve an unmet industrial, environmental or societal need.

Spheryx announces the addition of Dr. Ross Boltyanskiy in the roll of Senior Scientist. Dr. Boltyanskiy received his PhD in physics from Yale University, and was a Postdoctoral Research Fellow at Memorial Sloan Kettering. Dr. Laura Phillips, President and CEO, stated “We are delighted to have Dr. Boltyanskiy on board. With his expertise in microscopy, opto-mechanical technology and data visualization, he is a welcome addition to the Spheryx team.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Introduces xSight, a Revolutionary Particle Characterization Instrument, at PepTalk: The Protein Science Week, January 14-18, 2019

Spheryx will introduce xSight with live demonstrations at one of the largest annual gatherings of protein science researchers in the world. Results from Spheryx’s recent work, published in the Journal of Pharmaceutical Sciences, will also be presented at the conference.

New York, NY – Spheryx, Inc. announces the demonstration of its new particle characterization instrument, xSight, at PepTalk: The Protein Science Week in the Exhibit Hall, Booth 613, at the San Diego Hilton Bayfront, San Diego. The weeklong conference, January 14-18, is one of the largest annual gatherings of protein science researchers in the world, attracting over 1,300 participants. PepTalk features leading speakers from academia, biotech and pharma who bring global expertise and perspective to the forefront.

xSight implements Spheryx’s proprietary technology, Total Holographic Characterization^®. This revolutionary instrument is capable of detecting, counting and characterizing sub-visible particles in complex heterogeneous mixtures such as protein aggregates and silicone oil droplets, as well as other contaminants found in biologic formulations. xSight features new capabilities including multi-color laser sources and temperature control as well as the ability to eliminate cross-contamination with custom disposable 8-channel microfluidic sample chips. Dr. Laura Philips, Spheryx President and CEO, will also be making a poster presentation at the conference titled “Detecting, Counting and Characterizing Sub-Visible Protein Aggregates with Holographic Video Microscopy” reporting the work that has just been published in the Journal of Pharmaceutical Sciences, a leading peer-reviewed journal serving the pharmaceutical community.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx’s xSight Wins 2018 R&D 100 Award, Known as the Oscar of Innovation

Spheryx’s xSight, their new analytical instrument for particle characterization, wins the R&D 100 Award that celebrates the top 100 revolutionary technologies in 2018.

New York, NY – Spheryx, Inc. announced today that their xSight won the 2018 R&D 100 Award. For the past 55 years, the annual R&D 100 Award has identified the 100 most innovative products, honoring R&D pioneers and their revolutionary ideas in science and technology. Spheryx’s xSight was selected for its ground-breaking capabilities in particle characterization. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Panels of expert judges including consultants, university faculty members, and industrial researchers selected the finalists and determined the winners. Other 2018 winners include: The Dow Chemical Company, MilliporeSigma, MIT Lincoln Laboratory, NASA, Varian Medical Systems, Thermo Fisher Scientific, Toyota, and Los Alamos National Laboratory (see complete list of the winners). Winners were announced at a black-tie gala on Nov. 16 at the Waldorf Astoria in Orlando, FL. Spheryx CEO Dr. Laura Philips, who accepted the award at the ceremony, stated “We are honored that Spheryx’s xSight is included in such an august group of products from companies and institutions that are such household names. The R&D 100 Award is a testament to the revolutionary capabilities of xSight and its ability to meet critical needs across multiple industries.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Introduces xSight, a Revolutionary Particle Characterization Instrument, at the 10th Annual PEGS Europe November 12-16, 2018

Spheryx will introduce xSight with live demonstrations at a leading international conference on protein-based therapeutics.

New York, NY – Spheryx, Inc. is excited to demonstrate its new particle characterization instrument, xSight, at the 10th Annual PEGS Europe, November 12-16 in the Exhibit Hall at the Lisbon Congress Center in Lisbon, Portugal. PEGS Europe is a weeklong event that draws an international delegation of participants interested in collaborating and sharing best practices in the areas of protein and antibody engineering, oncology, expression, analysis, immunogenicity, and therapeutics.

xSight is based on Spheryx’s proprietary technology, Total Holographic Characterization^®. This revolutionary instrument is capable of detecting, counting and characterizing sub-visible particles in complex heterogenous mixtures such as protein aggregates and silicone oil droplets, as well as other contaminants found in biologic formulations. xSight features new capabilities including multi-color laser sources and temperature control and the ability to eliminate cross-contamination with custom disposable multi-channel microfluidic sample chips. xSight’s capabilities will be demonstrated at exhibition booth #214 throughout the conference. Dr. Laura Philips, Spheryx President and CEO, will also be making a poster presentation at the conference titled “Detecting, Counting and Characterizing Sub-Visible Protein Aggregates with Holographic Video Microscopy”.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents Paper on Characterization of Large Particle Contaminants in CMP Slurries at International Conference on Planarization/CMP Technology 2018

Spheryx presents a paper demonstrating the capabilities of Total Holographic Characterization^® for quantitatively detecting and characterizing large particle contaminants in chemical mechanical planarization slurries at ICPT 2018 in Seoul, Republic of Korea.

New York, NY – Spheryx announces the presentation of a paper entitled “Holographic Characterization of Agglomerates in CMP Slurries” at the International Conference on Planarization/CMP Technology (ICPT) 2018. The conference is focused on chemical mechanical planarization (CMP), one of the most important processes in semiconductor manufacturing, and draws attendees from around the world to address current challenges in the semiconductor industry. The paper will be presented by Dr. Fook Chiong Cheong (Chief Technology Officer, Spheryx, Inc.) at 9:40 am October 16, 2018 in Geomungo Hall, K Hotel, Seoul, Republic of Korea. This work also will be published in the conference proceedings. Dr. Cheong’s co-authors are Priya Kasimbeg, Annemarie Winters, Jaroslaw M. Blusewicz, Ei-Hnin Hlaing, David B. Ruffner, Laura A. Philips, all of Spheryx, Robin V. Ihnfeldt, President, General Engineering and Research, and David G. Grier, Professor of Physics, New York University.

The paper discusses the application of Spheryx’s proprietary Total Holographic Characterization^® to measure the concentration of agglomerates in CMP slurries, to distinguish dense compact agglomerates from transient branched agglomerates, and to differentiate agglomerates from other contaminants such as oil droplets and polishing pad fragments.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Protein Aggregates in the Presence of Silicone Oil in Journal of Pharmaceutical Sciences

Spheryx publishes a paper demonstrating the capabilities of Total Holographic Characterization^® for distinguishing protein aggregates from silicone oil in the presence of surfactants in the peer-reviewed Journal of Pharmaceutical Sciences.

New York, NY – Spheryx announces the publication of an article entitled “Holographic Characterization of Protein Aggregates in the Presence of Silicone Oil and Surfactants” in the peer-reviewed journal, The Journal of Pharmaceutical Sciences. The article has been selected by the editors for inclusion in the Special Topic Issue of the Journal, which will be published as the January 2019 issue of the Journal.

Currently, the article can be found at https://doi.org/10.1016/j.xphs.2018.10.002. This Spheryx paper was authored by Priya Kasimbeg, Fook C. Cheong, David B. Ruffner, Jaroslaw M. Blusewicz, and Laura A. Philips. The paper demonstrates the advantages of Spheryx’s proprietary technology, Total Holographic Charaterization^®, in the interrogation of biologic pharmaceutical formulations in the presence of common contaminants. The paper discusses how the Spheryx technology distinguishes different species and determines accurate, quantitative concentrations of multiple species simultaneously.

 
About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx's xSight Selected as Finalist for the 2018 R&D 100 Awards

Spheryx’s xSight, their new analytical instrument for particle characterization, is a finalist for the R&D 100 Award that celebrates the top 100 revolutionary technologies this year.

New York, NY – Spheryx, Inc. announced today that their xSight has been named a finalist for the 2018 R&D 100 Award. For the past 55 years, the R&D 100 Award has identified the 100 most innovative products annually, honoring R&D pioneers and their revolutionary ideas in science and technology. Spheryx’s xSight was selected for its ground-breaking capabilities in particle characterization. Applications range from pharmaceuticals to semiconductors, solving critical problems in manufacturing, quality control and R&D.

Panels of expert judges including consultants, university faculty members, and industrial researchers select the finalists and determine the winners. Previous winners include entries from Fortune 500 companies, National Laboratories, and smaller companies. This year’s winners will be announced at a black tie gala on November 16 at the Waldorf Astoria in Orlando, FL.

 
About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Awarded Phase IIB Grant to Support the Development of Total Hologrqaphic Characterization®

Spheryx, Inc. was awarded a Phase II-B Small Business Innovation Research grant by the National Science Foundation to support the development of Total Holographic Characterization® for applications in research and development, quality control and manufacturing across multiple industries.

New York, NY – Spheryx, Inc. announced today that the National Science Foundation (NSF) has awarded the company a Phase II-B Small Business Innovation Research (SBIR) grant for $500,000 over 2 years. This new grant is a continuation of an earlier grant entitled “Total Holographic Characterization of Colloids Through Holographic Video Microscopy” and is for the development of their proprietary Total Holographic Characterization® technology. These highly competitive grants are intended to stimulate technological innovation and commercialization for small businesses.
 
Dr. Laura Philips, Founder, President and CEO, commented, “This Phase II-B SBIR grant will enable us to enhance the capabilities of our technology to address critical issues in research and development, quality control and manufacturing process control across a broad range of industries.  The newly funded program provides the resources we need to increase the speed and robustness of our measurements, thereby improving our ability to deliver cost reduction in semiconductor wafer polishing, quality control in biologics manufacturing, and contaminant identification in multiple product manufacturing processes.  The enhanced instrument also will continue to serve as a cutting edge research tool in leading research institutions.”

 
About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Presents at the American Chemical Society 92nd Annual Colloid and Surface Science Symposium

Spheryx will make two presentations at the ACS Colloids and Surface Science Symposium being held at Penn State University, on June 10-13.

New York, NY – Spheryx announces the presentation of two papers at the American Chemical Society 92nd Colloid & Surface Science Symposium. A poster will be presented on June 11 from 5:30-7:30 pm entitled “Oils in water: Distinguishing multicomponent emulsion mixtures with holographic video microscopy” in the Dean’s Hall and there will be an oral presentation on June 12 at 4:20 pm entitled “Detecting, counting and characterizing sub-visible protein aggregates with holographic video microscopy" in room 204, both at the Penn Stater Conference Center at Penn State University, State College, Pennsylvania. Dr. Laura Philips, President and CEO of Spheryx, Inc., will present both papers.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Advantages of Multi-Color Sources for Holographic Characterization of Particles in Optics Express

A paper demonstrating the advantages of using multiple lasers of different colors to enhance the capabilities of their proprietary technology, Total Holographic Characterization^®, for the detection and monitoring of particles in suspensions, has been published in the peer-reviewed journal Optics Express.

New York, NY – Spheryx announces the publication of an article entitled “Lifting Degeneracy in Holographic Characterization of Colloidal Particles Using Multi-Color Imaging” in the peer-reviewed journal, Optics Express. The article can be found at: https://doi.org/10.1364/OE.26.013239. This Spheryx initiative was authored by David B. Ruffner (VP of R&D), Fook C. Cheong (CTO), Jaroslaw M. Blusewicz (Scientific Software Developer), and Laura A. Philips (President & CEO). The paper demonstrates the advantages of additional information from multiple different colored lasers which enhances the accuracy of their proprietary technology, Total Holographic Charaterization^® and provides a simple theoretical model to understand the enhanced results.

Spheryx CEO, Dr. Laura Philips, stated “The work behind this paper has been an integral part of our development of xSight, our particle characterization instrument. This work has led to the inclusion of multi-color illumination in xSight, which will be available for sale early next year. This expanded capability will increase the size range for particle characterization to both smaller and larger particles than is available currently in our beta version product.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Perform Live Demonstrations of xSight, their Particle Characterization Instrument, at PEGS Boston: May 1-3, 2018

Spheryx will demonstrate their proprietary Total Holographic Characterization® technology at a leading international conference on protein-based therapeutics. The technology meets a critical need in the industry for the detection and characterization of protein aggregates, a safety hazard in biologic pharmaceuticals.

New York, NY – Spheryx, Inc. will be demonstrating their instrument, xSight, which is based on their proprietary technology, Total Holographic Characterization®, at PEGS Boston from May 1-3, 2018 in the Exhibit Hall at the Seaport World Trade Center. PEGS Boston is a weeklong event that draws an international delegation of nearly 2,200 participants interested in collaborating and sharing best practices in the areas of protein and antibody engineering, oncology, expression, analysis, immunogenicity, and therapeutics. xSight is able to detect and characterize protein aggregates, a known safety hazard in biologic pharmaceuticals, using technology based on holographic video microscopy.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx’s xSight Wins Prism Award for Most Innovative New Products in Optics and Photonics

Spheryx’s xSight won the Prism Award in the category of Test and Measurement as the most innovative new product in optics and photonics.

New York, NY – Spheryx, Inc. announced today that their product xSight won a Prism Award last night at the Prism Awards Gala at Photonics West in San Francisco. SPIE and Photonics Media sponsor the Prism Awards to recognize the most groundbreaking and innovative technologies in the optics and photonics industry. Spheryx was among 10 companies honored by a Prism Award, and won in the category of Test and Measurement.

An independent panel of leading industry experts, venture capitalists, luminaries, and visionaries considered innovation and impact as selection criteria when choosing the winners. Celebrating their 10th anniversary, the Prism Awards have become a leading international competition that honors the best new photonic products on the market. (http://www.photonicsprismaward.com/)

Dr. Laura Philips, President and CEO, accepted the award on behalf of Spheryx, “It is an honor to win a Prism Award and to join the ranks of industry leaders that have previously won this award such as General Electric, Agilent, Hamamatsu, Swamp Optics, and Optotune. Innovating new products is a team sport and I am proud of the Spheryx team that has created our winning product, xSight, to solve critical problems in industries as diverse as biologic pharmaceuticals and semiconductor manufacturing. This award endorses our belief that xSight’s innovative use of holographic microscopy will make products safer for consumers and more cost effective for producers to develop new products and improve quality assurance and manufacturing process control.”


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx’s xSight Selected as Prism Award Finalist in Competition for Most Innovative New Products in Optics and Photonics

Spheryx’s xSight has been selected as a finalist for the Prism Award, known as the Oscar of Optics and awarded annually to the best new photonics products on the market.

New York, NY – Spheryx, Inc. announced today that their product xSight has been selected to be a finalist for a Prism Award by an independent panel of leading industry experts, venture capitalists, luminaries, and visionaries. The Prism Award for Photonics Innovation is a leading international competition that honors the best new photonic products on the market. (http://www.photonicsprismaward.com/) The 2018 winners will be announced at a gala event on January 31, 2018 during SPIE Photonics West in San Francisco, CA.

The Prism Awards are a celebration of the best of the industry and recognize products that make a difference. The finalists and winners that are ultimately chosen, ranging from General Electric, Agilent, and Hamamatsu to Swamp Optics, Optotune, and WiTec, reflect the diversity of the program. Eugene Arthurs, CEO of award sponsor SPIE, stated, “We are grateful to help move the development of laser, illumination, scanning, and other technologies into the applications used in everything from your phone to automobile."

Dr. Laura Philips, President and CEO of Spheryx, commented, “We are honored to be a Prism finalist. Nomination for this prestigious award acknowledges xSight’s innovative technology which provides cutting-edge solutions to a wide range of industries from semiconductor manufacturing to biologic pharmaceutical formulation.”


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Publishes Results on Semiconductor Polishing Slurries in Applied Physics Letters

A paper demonstrating the feasibility of using Spheryx’s proprietary technology, Total Holographic Characterization^®, to monitor large particle contaminants in semiconductor polishing slurries has been accepted for publication in the peer-reviewed journal Applied Physics Letters.

New York, NY – Spheryx announces the publication of an article entitled “Holographic characterization of colloidal particles in turbid media” in the peer-reviewed journal, Applied Physics Letters, which can be found at http://scitation.aip.org/content/aip/journal/apl/111/15/10.1063/1.4999101. The work was a collaboration of Fook Chiong Cheong, Priya Kasimbeg, David B. Ruffner, Ei Hlaing, Jaroslaw M. Blusewicz and Laura A. Philips of Spheryx, Inc., and Professor David G. Grier of New York University. The paper demonstrates that Spheryx’s proprietary Total Holographic Characterization^® is an effective method for quantitatively detecting, counting and characterizing large particle contaminants in nanoparticle semiconductor polishing slurries. Dr. Laura Philips, President and CEO of Spheryx stated “This paper demonstrates that Spheryx’s Total Holographic Characterization^® is an invaluable tool for monitoring the quality of semiconductor slurries. Reducing large particle contaminants in slurries can improve yields and decrease costs in semiconductor manufacturing.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx awarded Ph II grant to modify tech for biologics industry
By Melissa Fassbender, 07-Jul-2017

Spheryx, Inc. has been awarded a $1.5m grant over two years to support modifications to the company’s propriety protein aggregation detection and monitoring technology.

http://www.outsourcing-pharma.com/Preclinical-Research/Analytical-services-company-Spheryx-awarded-Ph-II-NIH-SBIR-grant

Spheryx Awarded Phase II NIH SBIR Grant to Support Extension of Total Holographic Characterization^® to Biologics Industry

Spheryx, Inc. was awarded a Phase II Small Business Innovation Research grant by the National Institutes of Health to support the adaptation of Total Holographic Characterization^® to meet the specific requirements of the biologic pharmaceuticals industry.

New York, NY – Spheryx, Inc. announced today that the National Center for Advancing Translational Science (NCATS) of the National Institutes of Health (NIH) has awarded the company a Phase II Small Business Innovation Research (SBIR) grant for $1,500,000 over 2 years to support the modification of their proprietary Total Holographic Characterization^® technology to meet the specific needs of the biologics pharmaceutical industry. These highly competitive grants are intended to stimulate technological innovation and commercialization for small businesses.

Although a beta version of Spheryx’s xSight instrument for Total Holographic Characterization^® is currently available for sale to select customer/partner companies, xSight will require additional functionality to meet the needs of the biologics industry. Critical innovations funded by this grant include high volume sample handling, high-speed flow, and detailed three-dimensional structures of protein aggregates to distinguish them from other contaminants.

Dr. Laura Philips, Founder, President and CEO, commented, “This Phase II SBIR award will enable us to deliver a powerful tool for the biologics industry. Enhancement of xSight will support their efforts to create the next generation of biologic pharmaceutical products and ensure that they are safe for consumers.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Results on Model Water Quality Samples Published in Water Research

A paper describing the application of Spheryx’s proprietary technology, Total Holographic Characterization®, to the study and monitoring of water quality has been accepted for publication in the peer-reviewed journal Water Research.

New York, NY – Spheryx announces the publication of an article entitled “Holographic characterization of contaminants in water: Differentiation of suspended particles in heterogeneous dispersions” in the peer-reviewed journal, Water Research, which can be found at http://www.sciencedirect.com/science/article/pii/S0043135417304803. The work was a collaboration of Spheryx, Inc., Professor David G. Grier of New York University, and Professor Jeffrey McCutcheon and his research group at the University of Connecticut. Authors from Spheryx include Dr. Laura A. Philips, Dr. David B. Ruffner, Dr. Fook Chiong Cheong, Mr. Jaroslaw M. Blusewicz and Ms. Priya Kasimbeg. The paper demonstrates that Spheryx’s proprietary Total Holographic Characterization® is an effective method for quantitatively detecting and characterizing multiple types of individual sub-visible contaminants in water. The technology is fast enough for continuous concentration monitoring and can monitor multiple components simultaneously in complex heterogeneous mixtures.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Awarded NSF Research Experiences for Teachers Grant

Spheryx, Inc. was awarded an RET grant by the National Science Foundation to support a summer internship for a high school teacher. The grant will benefit Spheryx in their ongoing R&D and provide professional development for a local teacher.

New York, NY – Spheryx, Inc. announced today that the National Science Foundation (NSF) has awarded the company a Research Experiences for Teachers (RET) grant. NSF-funded RET grants enable science educators to conduct research at institutions on the frontiers of science and to bring new knowledge back into the classroom. Stacy Goldstein, a high school teacher at Midwood High School in Brooklyn, one of the most diverse high schools in New York City, will be the RET intern at Spheryx. As a certified Master Teacher, Ms. Goldstein is one of the best and brightest teachers and a leader in science, technology, engineering and math (STEM) education. She is also a successful practitioner of the POGIL Process, a powerful pedagogy for teaching STEM material. As a Master Teacher and POGIL practitioner, she is well positioned to disseminate the knowledge and experience she gains at Spheryx to her students and fellow teachers across the country. During her internship she will be working with Spheryx employees to develop applications for Spheryx’s proprietary Total Holographic Characterization® technology with their first product, xSight. Dr. Laura Philips, Spheryx CEO commented, “Spheryx is happy to have the opportunity to bring cutting edge technologies like Total Holographic Characterization® into classrooms where they can be part of STEM education that inspires our scientific leaders of the future. We look forward to having Stacy on the Spheryx team.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Perform Live Demonstrations of xSight, their Revolutionary Particle Characterization Instrument, at PEGS Boston May 1-4, 2017

Spheryx will demonstrate their proprietary Total Holographic Characterization® technology at a leading international conference on protein-based therapeutics. The technology meets a critical need in the industry for the detection and characterization of protein aggregates, a safety hazard in biologic pharmaceuticals.

New York, NY – Spheryx, Inc. will be demonstrating their new instrument, xSight, which is based on their proprietary technology, Total Holographic Characterization®, at PEGS Boston from May 1-4, 2017 in the Exhibit Hall at the Seaport World Trade Center. PEGS Boston is a weeklong event that draws an international delegation of nearly 2,200 participants interested in collaborating and sharing best practices in the areas of protein and antibody engineering, oncology, expression, analysis, immunogenicity, and therapeutics. xSight is able to detect and characterize protein aggregates, a known safety hazard in biologic pharmaceuticals, using technology based on holographic video microscopy. Dr. David Ruffner, Spheryx Vice President of Research and Development, will also be making a presentation at the conference entitled “Protein Aggregate and Contaminant Detection: Total Holographic Characterization®”. Dr. Laura Philips, President and CEO of Spheryx, stated, “PEGS Boston is a great venue to introduce xSight to the biologic pharmaceutical community. xSight is a powerful tool for monitoring protein aggregates as well as other contaminants such as silicone oil that are encountered in the development and manufacturing of protein-based pharmaceuticals.”


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx to Present at the Chemical Mechanical Planarization Users Group Symposium

Spheryx Chief Technology Officer, Dr. Fook C. Cheong will present results from Spheryx’s proprietary Total Holographic Characterization® technology applied to semiconductor polishing slurries.

New York, NY – Spheryx, Inc. Chief Technology Officer, Dr. Fook Chiong Cheong will be making an oral presentation entitled “Holographic Characterization of Agglomerates” at the Chemical Mechanical Planarization Users Group (CMPUG) Symposium on Advances in CMP Consumables, Materials and Tools, on April 13, 2017 in Portland, OR. The symposium is an international forum for academic researchers, industrial practitioners and engineers from around the world for the exchange of information on state-of-the-art research in CMP semiconductor technology. Dr. Cheong will be speaking on one of the symposium focus areas, the latest developments in metrology tools. Dr. Cheong’s presentation will describe the application of Spheryx’s proprietary technology, Total Holographic Characterization®, to the detection, monitoring and characterization of damaging agglomerates and large particle contaminants in CMP nanoparticle slurries. Dr. Laura Philips, Spheryx CEO stated: “Spheryx’s presentation to the CMP community is a great opportunity to introduce the technology behind Spheryx’s new instrument, xSight. xSight is a revolutionary tool for detecting large particles in CMP slurries and ultimately reducing costs and improving yields in the manufacture of semiconductor wafers.”


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs. For more information: https://www.spheryx.solutions/

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Introduces xSight: a Revolutionary Analytical Instrument for Sub-Visible Particle Characterization

Spheryx announces the availability of xSight, the first instrument capable of performing particle characterization using Spheryx’s proprietary Total Holographic Characterization^® technology.

New York, NY – Spheryx, Inc. announces the launch of their xSight beta program. Limited numbers of the xSight beta version are now available for sale. xSight is an instrument capable of performing Spheryx’s proprietary Total Holographic Characterization^® on sub-visible particles suspended in fluids, providing new insights for scientists and engineers from R&D to manufacturing. A limited number of xSights will be sold to select customer/partners who will work closely with experts at Spheryx to fine tune the design in real-world environments. Dr. Laura Philips, Spheryx President and CEO, stated “xSight is capable of addressing critical problems such as detecting dangerous protein aggregates in biologic pharmaceuticals and costly agglomerates in semiconductor polishing slurries, or monitoring contaminants in wastewater and QA in consumer products. We look forward to working with select companies in these industries to enhance innovation, improve safety and reduce costs. The beta program enables Spheryx experts to work closely with our customers in their locations to meet their particle characterization needs.” More information on the beta program and xSight can be found at the newly updated Spheryx website: https://www.spheryx.solutions.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization^® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.

Spheryx Announces Three Presentations at Pittcon 2017, the World’s Largest Conference for Laboratory Science

Spheryx will be making three presentations at Pittcon, Chicago, IL, March 6, 7, and 8 on their patented Total Holographic Characterization^® and its applications in biologics, semiconductors and water quality.

New York, NY – Spheryx, Inc. will present two oral presentations and one poster presentation at PittCon 2017 Conference and Exposition at McCormick Place, Chicago IL. Pittcon is the world’s largest annual premier conference and exposition on laboratory science and serves a wide array of industry, academic and government communities encompassing life sciences, pharmaceutical discovery and QA, food safety, environmental, bioterrorism and other emerging markets. The presentations will cover Spheryx’s patented Total Holographic Characterization\ and its applications to protein aggregation in biologics, quality assurance for semiconductor polishing slurries and wastewater monitoring. Dr. David Ruffner, Spheryx Vice President of R&D, will make two presentations entitled “Monitoring Changes in Protein Aggregation with Holographic Characterization”, March 7 at 8:50 am, and “Holographic Characterization of Large Particle Contaminants in Chemical Mechanical Planarization Slurries”, March 8 at 1:00 pm. Jaroslaw Blusewicz, Spheryx Scientist, will make a presentation entitled “Holographic Characterization of Contaminants in Wastewater”, March 6 at 8:30 am.


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially.

Spheryx Protein Aggregate Results Presented in Prestigious Venues: Presentations at PEGS Europe and Publication in Soft Matter

Results from Spheryx research on protein aggregates will be presented in two posters at PEGS Europe, the largest European event covering all aspects of protein and antibody engineering. Work performed in collaboration with scientists at New York University on the morphology of protein aggregates will be published in Soft Matter, a top tier, peer reviewed journal serving the physics, chemistry and biology research communities.

New York, NY – – Spheryx, Inc. is pleased to announce that the company will present two posters at PEGS Europe. The posters, entitled “A New Method for Protein Aggregate Detection: Total Holographic Characterization®” and “Distinguishing Protein Aggregates from Silicone Oil by Symmetry and Fractal Dimension” will be presented on November 3 and 4 at the EPIC SANA Lisboa Hotel, Lisbon, Portugal. PEGS Europe, the largest European event covering all aspects of protein and antibody engineering, brings together a cross section of protein scientists from leading biologics producers and research institutions. Additional information about PEGS Europe can be found at www.pegsummiteurope.com. Spheryx also announces the publication of an article entitled “Holographic Characterization of Colloidal Fractal Aggregates” in Soft Matter (DOI: 10.1039/C6SM01790H) in collaboration with Prof. David Grier and his research group at New York University. This paper demonstrates that Total Holographic Characterization® can assess the shape, size and composition of pharmaceutically important protein aggregates as well as other irregularly shaped particles.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company developing Total Holographic Characterization®. The breakthrough proprietary technology, based on holographic video microscopy, enables the real-time, sub-microscopic characterization of multi-component colloidal materials. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, safety and cost savings.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or results to differ materially.

Spheryx Awarded Phase II NSF SBIR Grant to Support Commercialization of Total Holographic Characterization®

Spheryx, Inc. was awarded a Phase II Small Business Innovation Research grant by the National Science Foundation to support the development of Total Holographic Characterization® for applications in many industrial applications including semiconductor manufacturing and biologic pharmaceuticals.

New York, NY – Spheryx, Inc. announced today that the National Science Foundation (NSF) has awarded the company a Phase II Small Business Innovation Research (SBIR) grant for $748,000 to support commercialization of their proprietary Total Holographic Characterization® technology. These highly competitive grants are intended to stimulate technological innovation and commercialization for small businesses.

Early applications of this technology include product development, quality assurance and process control in the semiconductor manufacturing and biologic pharmaceuticals industries. A beta version of the instrument will be available for sale in 2017 to select customer/partner companies.

Dr. Laura Philips, Founder, President and CEO commented, “This Phase II SBIR award is a testament to the power of the technology to provide solutions to critical problems in major industry sectors where Total Holographic Characterization® has the potential to enhance innovation, improve performance, increase quality and decrease manufacturing costs. The successful result of the proof-of-principle work completed under a Phase I grant makes us confident that the support of this Phase II grant will enable Spheryx to deliver this powerful new technology to the market.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held company developing Total Holographic Characterization®. This breakthrough proprietary technology uses holographic video microscopy to characterize particles in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Announces Three Presentations at the 90th Annual American Chemical Society Colloid & Surface Science Symposium

Spheryx will be making three presentations at ACS Colloids at Harvard University, Cambridge, MA on June 6 , 7 and 8 on their patented Total Holographic CharacterizationTM and its applications.

New York, NY – Spheryx, Inc. will present two oral presentations and one poster presentation at the 90th Annual ACS Colloid & Surface Science Symposium at Harvard University, Cambridge, MA , June 5-8. The presentations will cover Spheryx’s patented Total Holographic Characterization™ and its applications to protein aggregation in biologics and quality assurance for semiconductor polishing slurries. Dr. David B. Ruffner, Director of Analytical Sciences and Research Scientist, will make a poster presentation at 5:30 pm on June 6 entitled “Total holographic characterization of multicomponent colloidal suspensions” and an oral presentation at 11:10 on June 7 entitled “Holographic characterization of protein aggregates”. Dr. Fook C. Cheong, Chief Technology Officer, will make an oral presentation at 11:20 on June 8 entitled “Characterizing the size distribution, composition and stability of chemical mechanical polishing slurry agglomerates”.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx CEO, Dr. Laura Philips Interviewed in CEOCFO Magazine

In the CEOCFO Magazine article, Dr. Philips discusses Spheryx’s revolutionary technology with applications across multiple industries in R&D, quality assurance and manufacturing.

New York, NY – Spheryx, Inc. announced today that their President, CEO and Founder, Dr. Laura Philips was profiled in CEOCFO Magazine. The article, based on an interview with Dr. Philips, can be found at http://ceocfointerviews.com/interviews/Spheryx16.htm. In the article Dr. Philips addresses questions about Spheryx’s Total Holographic CharacterizationTM technology and applications in a broad array of industries, including biologic pharmaceuticals, CMP slurries used in the semiconductor industry, and consumer products. She also comments on the challenges and rewards of building a company around a disruptive technology that can optimize product quality while also reducing costs to both manufacturers and consumers.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM of colloidal materials. The breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Awarded an NIH SBIR Grant to use Total Holographic Characterization™ for Protein Aggregate Detection

Spheryx, Inc. was awarded a Small Business Innovation Research grant by the National Center for Advancing Translational Sciences of the National Institutes of Health to support the development of Total Holographic Characterization™ for analyzing protein aggregates, a critical need for the >$150 Billion biologics industry.

New York, NY – Spheryx, Inc. announced today that the National Institutes of Health (NIH) has awarded the company a Small Business Innovation Research (SBIR) grant entitled “Instrument for Analyzing Protein Aggregates”. This award from the National Center for Advancing Translational Sciences of the NIH will fund the development of their patented Total Holographic Characterization™ for analyzing protein aggregates.

Dr. Laura Philips, President and CEO stated, “The FDA has advised in its 2014 Guidance for Industry that ‘It is critical for manufacturers of therapeutic protein products to minimize protein aggregation to the extent possible’, while acknowledging that the technology does not currently exist to accomplish this goal. Protein aggregation occurs in the biopharmaceutical pipeline, from development, formulation, and manufacturing to storage and point of use. This NIH SBIR grant will enable Spheryx to develop Total Holographic Characterization™ for monitoring protein aggregates in pharmaceutical formulation and manufacturing.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM of colloidal materials. The breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Announces Presentations and Live Demonstration of Total Holographic Characterization™ at the American Chemical Society National Meeting

Spheryx will be demonstrating Total Holographic Characterization™ and making an oral presentation and a poster presentation at the 251st American Chemical Society National Meeting and Exposition from March 13-16 in San Diego, CA.

New York, NY – Spheryx, Inc. will demonstrate the capabilities of Total Holographic Characterization™ at the 251st American Chemical Society National Meeting and Exposition, from March 13-15, in booth 1435 where Chief Technology Officer Dr. Fook Cheong will be performing particle characterization analyses. Dr. David Ruffner, Director of Analytical Services, will make an oral presentation titled “Holographic Characterization of Individual Colloids in Complex Mixtures” on March 16 at 9:30 am in room 24B, and a poster presentation titled “Holographic Imaging of Protein Aggregates, Slurry Agglomerates, and Wastewater Contaminants” on March 13 at 8:00 pm in Hall E of the San Diego Convention Center. Dr. Laura Philips, Spheryx CEO, stated “The ACS meeting provides a great forum to introduce our technology to a wide array of industries where Total Holographic Characterization™ can become a useful tool to solve particle characterization problems from R&D to quality assurance and manufacturing process control.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Announces Two Presentations at PittCon, the World’s Largest Conference for Laboratory Science

Spheryx will be making two presentations at PittCon in Atlanta, GA on Monday and Tuesday, March 6 and 7 on their patented Total Holographic Characterization™ and its applications.

New York, NY – Spheryx, Inc. will present at the PittCon 2016 Conference and Expo, the world’s largest annual premier conference and exposition on laboratory science. The presentations will cover Spheryx’s patented Total Holographic Characterization™ and its applications to protein aggregation in biologics, quality assurance of semiconductor polishing slurries, wastewater monitoring, and consumer products characterization. Dr. David Ruffner, Director of Analytical Sciences and Research Scientist, will make a presentation at 1 pm on Tuesday, March 7, and Jaroslaw Blusewicz, Scientist, will make a presentation on Monday, March 6 at 1 pm. Both presentations will take place on the Exposition Floor of the Georgia World Congress Center, Atlanta, GA.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization™ of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx’s Journal of Pharmaceutical Sciences Paper Selected to be Feature Article

The prestigious Journal of Pharmaceutical Sciences announced today that their editors have selected Spheryx’s paper on the characterization of protein aggregates to be a feature article in the March edition of the journal.

New York, NY – Spheryx, Inc. announced today that their journal article entitled “Holographic Characterization of Protein Aggregates”, was selected by the journal’s Editoral Team to be displayed under Features on the editors of the Journal of Pharmaceutical Sciences’ new website, http://www.jpharmsci.org. Dr. Laura A. Philips, CEO, and Dr. David B. Ruffner, Director of Analytical Services, of Spheryx collaborated with Prof. David G. Grier and Prof. Michael D. Ward professors of physics and chemistry, respectively at New York University on the work presented in the paper. Prof. Grier is also a co-founder of Spheryx, and Chair of the Spheryx Scientific Advisory Board. Dr. Philips stated “Being featured by the editors on the Journal’s website is excellent exposure for the capabilities of Spheryx’s patented Total Holographic Characterization™ in the detection and monitoring of protein aggregates.”

Link to full article: http://www.jpharmsci.org/article/S0022-3549(15)00248-8/fulltext

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization™ of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Technology Published in the Journal of Pharmaceutical Sciences

The prestigious Journal of Pharmaceutical Sciences announced today that it released the on-line version of Spheryx’s article on the characterization of protein aggregates, to be published in print in an upcoming volume of the journal.

New York, NY – Spheryx, Inc. announced today that their journal article entitled “Holographic Characterization of Protein Aggregates”, is now available on-line in the prestigious, peer-reviewed Journal of Pharmaceutical Sciences and will be available in print in an upcoming volume of the Journal. Dr. Laura A. Philips, CEO and Dr. David B. Ruffner, Director of Analytical Services are two of the co-authors of the article. Other authors include Prof. David G. Grier and Prof. Michael D. Ward professors of physics and chemistry at New York University. Prof. Grier is also a co-founder of Spheryx, and Chair of the Spheryx Scientific Advisory Board.

The article describes the application of holographic video microscopy to the detection of protein aggregates, a safety concern for the patients of protein-based biologic pharmaceuticals. The technology is compared, in the article, to other technologies currently used in the field. Dr. Philips stated, “The publication of this article is an opportunity to present the power of holographic characterization to the pharmaceutical development community where the technology may find applications in R&D and manufacturing biologic pharmaceuticals.” Prof. Grier added, “It is gratifying to see that technology based in fundamental physics can find important applications to real world problems.”

The article can be found at: http://dx.doi.org/10.1016/j.xphs.2015.12.018.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization™ of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Dr. Fook C. Cheong joins Spheryx, Inc. as Chief Technology Officer

Dr. Fook C. Cheong, expert optical designer and physicist, joins Spheryx as the company begins to design Total Holographic Characterization™ instrument prototypes for manufacture.

New York, NY – Spheryx, Inc. announced today that Dr. Fook C. Cheong is joining the Spheryx leadership team as the Chief Technology Officer. Dr. Cheong received his PhD in physics at the National University of Singapore. In 2007, he joined the research group of Prof. David Grier, a co-founder of Spheryx, at New York University, as a Postdoctoral Fellow. While a member of the Grier group, Dr. Cheong performed seminal work on Total Holographic Characterization™ and is the author of several of the key patents exclusively licensed to Spheryx by NYU. Most recently, Dr. Cheong has been Design Engineer, at Thorlabs, Inc.

Dr. Laura Philips, President and CEO of Spheryx, stated “We are delighted to have Dr. Cheong join Spheryx to lead the effort in designing Total Holographic Characterization™ instrumentation for commercialization. He has the technical expertise and the leadership skills to shepherd the technology to market for Spheryx.” Dr. Cheong responded “I am looking forward to bringing Total Holographic Characterization to market. It is exciting to see the technology that I helped to create ready to have an impact in industries like semiconductor manufacturing, pharmaceutical development and manufacturing, quality control in water treatment, and consumer products.”

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Awarded an NSF SBIR Supplemental Funding Grant to further development of Total Holographic Characterization™

Spheryx, Inc. was awarded a Supplemental Small Business Innovation Research grant by the National Science Foundation to continue the development of a novel approach to analyzing the physical properties of colloidal dispersions for application to CMP slurries for the semiconductor industry.

New York, NY – Spheryx, Inc. announced today that the National Science Foundation (NSF) has awarded the company a Supplemental Small Business Innovation Research (SBIR) grant. The focus of the funded work is on the application of Total Holographic Characterization™ to CMP slurries used in the manufacturing of semiconductor wafers. This grant is intended to bridge the gap between Phase I and possible Phase II funding. It helps accelerate the Phase I project to the commercialization stage by matching 50% of third party investments, extending the R&D effort beyond the current grant to meet technical requirements of third party investors. The patented technology has the potential to improve quality assurance for CMP slurries and reduce waste in the manufacturing process of semiconductor wafers.

Dr. Laura Philips, President and CEO of Spheryx stated “Waste resulting from imperfections in wafers caused by agglomerates in CMP slurries is a serious problem for the semiconductor industry. Total Holographic Characterization™ has the unique ability to detect large particles in turbid media, which is critical to controlling the occurrence of these agglomerates. We are delighted that the NSF is supporting our efforts at tackling this important problem.”


About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization™ of colloidal materials. Spheryx’s breakthrough proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, thereby offering unprecedented insights into these materials’ characteristics. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx’s Total Holographic Characterization™ Selected as a Finalist for a 2015 R&D 100 Award

Spheryx’s Total Holographic CharacterizationTM has been selected by an independent judging panel and the editors of R&D Magazine as a finalist for a 2015 R&D 100 Award, which recognizes the 100 most technologically significant products introduced in the past year. The winners will be announced on November 13 at the R&D 100 annual gala in Las Vegas, NV.

New York, NY –Spheryx, Inc. announced today that their technology for Total Holographic Characterization has been selected by an independent judging panel and the editors of R&D Magazine as a finalist for a 2015 R&D 100 Award in the Analytical/Test category.

R&D 100 Awards recognize the 100 most technologically significant products introduced in the past year. Selection is based on products’ design, development, testing and production of products and on the impact they are having in their fields.

The winners of the 2015 R&D 100 Awards will be announced at the R&D 100 annual gala banquet to be held on Friday, November 13 at Caesars Palace in Las Vegas, Nevada, as part of the 2015 R&D 100 Technology Conference.

Termed "the Oscars of Invention", previous winners include: the fax machine, halogen lamps, HDTV and the ATM. More recent breakthroughs that have earned R&D 100 Awards include next-generation magnetic resonance imaging machines, laser-based metal-forming tools, and the building blocks for fusion experiments.

Dr. Laura Philips, President and CEO of Spheryx commented, “It is an honor to have Total Holographic Characterization receive this level of recognition as a finalist for the R&D 100 award, especially considering the caliber of products that have previously received this award.”

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx Awarded an NSF SBIR Grant to Develop Total Holographic Characterization™ for Commercialization

Spheryx, Inc. was awarded a Small Business Innovation Research grant by the National Science Foundation to support the development of a novel approach to analyzing the physical properties of colloidal dispersions which has diverse applications across multiple industries in the $5 billion particle characterization market.

New York, NY – Spheryx, Inc. announced today that the National Science Foundation (NSF) has awarded the company a Small Business Innovation Research (SBIR) grant. This award will fund the development of a novel approach to analyzing the physical properties of colloidal dispersions, Total Holographic Characterization™, based on holographic video microscopy.

This patented technology, exclusively licensed to Spheryx, will have immediate applications in industries as diverse as pharmaceuticals, cosmetics, personal care products, petrochemicals, coatings and food, all of which rely on the properties of colloidal dispersions. The worldwide market for particle characterization exceeded $5 billion per year in 2012. The funded work extends the state­-of-the-­art in particle characterization by providing simultaneous information about both the size and the composition of individual particles in suspensions. In a matter of minutes, Spheryx’s fast precise holographic measurements build up a clear picture of a sample’s composition, even for complex multicomponent mixtures and blends.

Dr. Laura Philips, President and CEO stated, “This SBIR award is an acknowledgement that these innovations to Total Holographic Characterization, if successful, can be a powerful tool for industry. Access to new dimensions of information will be useful for product development, process control and quality assurance in all industrial sectors that rely on properties of colloidal materials, thereby increasing opportunities for innovation, enhancing product performance, and decreasing manufacturing costs.” Dr. David Ruffner, Director of Analytical Services and Research Scientist added “These funds will be committed to transforming holographic characterization from ideal laboratory samples to real world industrial materials. The improvements will allow us to characterize particles in these non-ideal suspensions with nanometer resolution in size and part per thousand in refractive index.”

No other particle characterization technique offers such a wealth of particle ­resolved information. The delivery of a 100 ­fold acceleration in performance, funded by this grant, will enable applications in large volume and high throughput applications. Spheryx plans to use the resulting real­time capabilities to improve manufacturing efficiency by identifying and helping to correct process deviations and failures. In so doing it will reduce product costs in all of the industrial sectors that develop and sell colloidal materials.


Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Spheryx to Present at PittCon and American Chemical Society Meetings

Spheryx will give poster presentations at PittCon, the world's largest annual conference and exposition for laboratory science, on March 11, 2015 at 1 pm in New Orleans, and at the American Chemical Society National Meeting and Exposition on March 22nd, 2015 at 6 pm in Denver.

New York, NY – Spheryx, Inc. will present at two upcoming meetings, the PittCon 2015 Conference and Expo, the world’s largest annual premier conference and exposition on laboratory science, and the 249th American Chemical Society National Meeting and Exposition. The presentations will cover Spheryx’s technology for Total Holographic Characterization™ based on holographic video microscopy developed in the laboratory of Prof. David Grier, Professor of Physics at New York University, Director of NYU's Center for Soft Matter Research, and co-founder of Spheryx. The authors of the presentation are Spheryx President, CEO and co-founder, Dr. Laura Philips, Dr. David Grier and Dr. Fook Cheong, also a co-founder of Spheryx. Dr. Philips will be making the presentations.

The presentation at PittCon will take place at 1 pm on March 11, in Hall F of the Ernest N. Morial Convention Center, New Orleans, LA. The presentation at the National American Chemical Society meeting will take place at 6 pm on Sunday, March 22, in Hall E, and at 8 pm on Monday, March 23, in Hall C of the Colorado Convention Center, Denver, CO.

Learn more about the American Chemical Society.

Learn more about PittCon.

Spheryx Announces Completion of Successful Seed Round Fund Raising, New Facilities, and David Ruffner, PhD joins Spheryx

Spheryx has completed a successful seed round financing, enabling the company to move into new space, and to advance the commercial development of Total Holographic Characterization™. Spheryx has hired David B. Ruffner, PhD, an internationally noted expert in holographic video microscopy with deep ties to the Grier research group at NYU, to be Director of Analytical Services and Research Scientist.

New York, NY – Spheryx, Inc. is pleased to announce the completion of a successful seed round financing. The proceeds will be used to finance product development and general business expenses for the commercialization of Spheryx’s technology for Total Holographic Characterization™.

The new funds have already been put to work as Spheryx expands with a move into new space and the hiring of David B. Ruffner, PhD to be Director of Analytical Services and Research Scientist for Spheryx. Dr. Ruffner brings extensive experience in holographic video microscopy, the breakthrough technology that is at the core of Total Holographic Characterization™, with numerous publications and a reputation for excellence in the field. Dr. Ruffner has deep ties to the Research Group of Prof. David Grier, Professor of Physics at New York University, Director of NYU's Center for Soft Matter Research, and co-founder of Spheryx.

Spheryx CEO, Dr. Laura Philips, stated “Spheryx is gaining a strong talent with the addition of Dr. Ruffner. His expertise in holographic video microscopy will be invaluable as we deliver state-of-the-art measurements to current customers and to advance the robust, turn-key, commercial instruments currently in development.” Dr. Ruffner responded “I am excited to be joining the company at this early stage of commercialization. I believe that Total Holographic Characterization™ has the potential to provide truly transformative capabilities to the market.” Total Holographic Characterization™ is the revolutionary technology to characterize particles in colloids and emulsions, which is exclusively provided by Spheryx, Inc.

About Spheryx, Inc.
Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic CharacterizationTM capabilities. The breakthrough proprietary technology, based on holographic video microscopy, enables the real-time, sub-microscopic characterization of multi-component colloidal materials. Applications include research and development, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, safety and cost savings.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

The Journal Soft Matter honors Holographic Video Microscopy Technology work by Spheryx , Inc. Co-Founder, Prof. David Grier, in its 10th Anniversary Edition

The cover story of the 10th Anniversary Edition of the journal Soft Matter will be work based on Spheyrx’s Total Holographic Characterization™ technology. Being selected for this honor is a tribute to the potential of the technology and the quality of the science performed by Prof. David Grier, co-founder of Spheryx and Professor of Physics at New York University and his colleagues at NYU.

New York, NY – Spheryx, Inc. is pleased to announce that an article submitted by David Grier, co-founder of Spheryx and Professor of Physics at New York University, has been selected to be the cover article in its 10th Anniversary Issue of Soft Matter, a journal of the Royal Society of Chemistry. The image on the cover is a representation of the data from Spheryx’s Total Holographic Characterization™.

The article shows how Spheryx’s technology for Total Holographic CharacterizationTM can guide the design and synthesis of colloidal materials by rapidly measuring the properties of individual colloidal particles. The citation for the article is “Celebrating Soft Matter’s 10th Anniversary: Monitoring colloidal growth with holographic microscopy” by Chen Wang, Hagay Shpaisman, Andrew D. Hollingsworth and David G. Grier, Soft Matter, 2015, vol. 11, pgs. 1062-1066.

Spheryx CEO, Dr. Laura Philips, stated “It is wonderful to see that this revolutionary technology is receiving such recognition. We look forward to continuing to demonstrate the power of the technology in commercial applications pursued by Spheryx.” Prof. Grier replied, “It’s always exciting when academic research breaks through into the real world. Having this work honored by Soft Matter at the same time that Spheryx is bringing it to market is just exceptional.” The underlying work for the article was supported primarily by a grant from Procter & Gamble™, and in part by NASA and the National Science Foundation. The technology described in the article is exclusively license to Spheryx, Inc. where it is being developed for a variety of commercial applications.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Please visit SoftMatter to view the complete article.

You may also view the New York University press release.

Spheryx Technology Profiled as 1 of 10 World Changing Ideas in the December Issue of Scientific American

Scientific American identified the technology behind Spheryx, Inc. as one of ten world changing ideas in their December cover story. The revolutionary capabilities enabled by video cameras for nanoparticles has applications across a wide range of industries to enhance product development, quality assurance and manufacturing of colloidal materials.

New York, NY – Spheryx, Inc., the developer of proprietary analytical capabilities for colloidal materials, announced today that the technology behind Spheryx’s Total Holographic CharacterizationTM is profiled in Scientific American’s December cover story entitled “World Changing Ideas”.

Spheryx’s novel technology is one of 10 new scientific discoveries that Scientific American magazine predicts will drive progress in the years ahead. This new form of holographic microscopy developed by Dr. David Grier, a physicist at New York University and Co-Founder of Spheryx, is described in the section of the article titled “Video Cameras for Nanoparticles, Electron microscope resolution for quick-and-dirty industrial applications”.

Spheryx CEO and Co-Founder, Dr. Laura Philips, stated “We are delighted that Scientific American has highlighted the revolutionary nature of the technology, which provides a new window into complex colloidal mixtures, with applications across a wide range of industries. Total Holographic Characterization has the potential to improve the quality, performance and cost of products that people purchase, use and consume everyday.”

The technology described in the article is exclusively licensed to Spheryx, Inc. where it is being developed for a variety of commercial applications.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially. These risks and uncertainties include, among others: the results, timing and costs of our studies; our ability to obtain future funding on acceptable terms; the possible impairment of, or inability to obtain intellectual property rights; and innovation by our competitors.

Please visit www.scientificamerican.com to view the complete article. There may be a charge for this service.

Spheryx Awarded Phase IIB NIH SBIR Grant to Support the Development of Total Holographic Characterization® for Biologic Pharmaceutical Applications

Spheryx, Inc. was awarded a Phase IIB Small Business Innovation Research grant by the National Institutes of Health to support the development of their Total Holographic Characterization® for applications in the pharmaceutical industry, particularly protein-based pharmaceuticals.

New York, NY – Spheryx, Inc. announced today that the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) has awarded the company a Phase IIB Small Business Innovation Research (SBIR) grant for $2,000,000 over 2 years. This new grant is a continuation of an earlier grant entitled “Instrument for Characterization of Protein Aggregates” and will support further development of Spheryx’s proprietary Total Holographic Characterization® technology. These highly competitive grants are intended to stimulate technological innovation and commercialization for small businesses.

Previous funding from Phases I and II of this SBIR grant resulted in two publications in the Journal of Pharmaceutical Sciences (here, here), demonstrating the capabilities of Spheryx’s technology to monitor contaminants in biologic products, with Spheryx’s first particle characterization product, xSight.

Dr. Laura Philips, Spheryx Founder, President and CEO, commented, “This Phase IIB SBIR grant will enable us to enhance the capabilities of our technology in direct response to feedback from the pharmaceutical industry. These enhancements will enable our products to meet the needs of quality control and manufacturing process control to increase biologic product safety for consumers while also decreasing costs of product development and manufacturing. We are pleased that this grant further validates the promise of our technology for meeting the needs of the biologics industry.”

About Spheryx, Inc.

Spheryx, Inc. is a privately held analytical services and instruments company providing Total Holographic Characterization® of colloidal materials. Spheryx’s proprietary technology uses holographic video microscopy to characterize each particle in colloidal dispersions and multi-component colloidal mixtures, offering unprecedented insights into these materials’ characteristics. Applications include R&D, quality assurance and manufacturing process control across a broad spectrum of industries, where characterization of colloids can enhance innovation, improve safety and reduce costs.

Note: This news release contains forward-looking statements regarding future events. These statements are just predictions and are subject to risks and uncertainties that could cause the actual events or result to differ materially.